Ubiquitin-activating Enzyme E1
Ubiquitin-activating enzyme E1 catalyzes the first stage of the multistep enzymatic cascade of ubiquitination. Using ATP, the E1 enzyme binds to a ubiquitin molecule which is subsequently transferred to E2 enzymes, E3 enzymes, and then finally the target protein.
Products for Ubiquitin-activating Enzyme E1
- Cat.No. Product Name Information/Activity
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BCC7988
NSC 624206
NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation.
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BCC4470
PYR-41
PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 μM, with little activity at E2 and E3.
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BCC4253
PYZD-4409
PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC50 of 20 μM (cell-free enzymatic assay). PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells.
