D4 Receptor

D4 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D3 and D5. They are located primarily in the frontal cortex, midbrain, amygdala and the cardiovascular system. A role in cognition and emotion has been proposed.

Products for D4 Receptor

Cat.No. Product Name Information/Activity
BCC6224 A 412997 dihydrochloride Selective D<sub>4</sub> agonist
BCC7293 ABT 724 trihydrochloride ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.
BCC6919 PD 168077 maleate PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.
BCC7330 Ro 10-5824 dihydrochloride Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.
BCC2054 WAY-100635 maleate salt WAY-100635 maleate salt is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate salt has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate salt is also a potent dopamine D4 receptor agonist.
BCC7440 Fananserin Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor.
BCC5696 L-741,742 hydrochloride 874882-93-6
BCC5695 L-745,870 trihydrochloride 866021-03-6
BCC7702 PD 168568 dihydrochloride 210688-56-5
BCC7467 PNU 96415E 170856-41-4