Products with Cancer chemoprevention Bioactivity

Explore BioCrick products associated with Cancer chemoprevention biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN5768	Xanthohumol
Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. Xanthohumol may play a role in improving cognitive flexability in young animals. Xanthohumol has beneficial effects on markers of metabolic syndrome, it lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.Valosin-containing protein (VCP) inhibitor. Binds to the N domain of VCP, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC<sub>50</sub> = 50.3 <span class='symbol'>μ</span>M).
BCN5781	Isofuranodiene
1. Isofuranodiene has anticancer activity, by inhibiting the proliferation and inducing apoptosis in cancer cells. 2. Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. 3. Isofuranodiene can induce apoptosis in colon cancer cells in a time and concentration-dependent manner suggesting a potential role as models for the development of chemopreventive agents. 4. Isofuranodiene at concentrations of 25 and 12.5 lM alone, or in combination with 50 nM nerve growth factor (NGF) , shows a marked stimulation of neuritogenesis,which appears to be a promising neurotrophic and neuroprotective agent.
BCN5852	Cycloart-25-ene-3,24-diol
1. (24R)-Cycloart-25-ene-3beta,24-diol exhibits inhibitory effects on both Epstein-Barr virus early antigen (EBV-EA) and (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3- hexemide (NOR 1) activation, it may be an anti-tumor promoter.
BCN5905	6,7-Dihydroxycoumarin
6,7-Dihydroxycoumarin(Esculetin) has various biological and pharmaceutical properties including anti-edema, anti-inflammatory, anti-tumour, hepatoprotective, anti-osteoarthritis and anti-rheumatoid arthritis effects. It inhibits lipoxygenases (LOs), p42/44 MAPK activation, PI3-kinase activation, as well as NF-kappaB and AP-1 activation, it exhibits competitive inhibition against the oxidation of 3-(3,4-dihydroxyphenyl)- alanine by mushroom, the IC50 value of is 43 microM.
BCN5920	Theaflavin 3,3'-di-O-gallate
Theaflavin-3,3'-digallate(TF3), an inducer of oxidative stress, which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF; suggests that TF3 might serve as a potential anti-angiogenic agent for cancer treatment. TF3 and lactic acid combinations can reduce Herpes Simplex Virus(HSV) infectivity.

Cancer chemoprevention Bioactivity Products