Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1188 | 4-Hydroxycinnamamide |
| 1. 4-Hydroxycinnamamide has antioxidant activity. 2. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases. | |
| BCN1189 | Alphitolic acid |
| 1. Alphitolic acid is an anti-inflammatory triterpene, has antitumour activity in oral squamous cell carcinoma (OSCC) cells. 2. Alphitolic acid can suppress the proliferation of SCC4 and SCC2095 OSCC cells with IC50 values of 12 and 15 uM, respectively, via apoptotic induction, this drug effect on apoptosis is, in part, associated with its ability to block Akt-NF-κB signalling; it could as an ingredient in functional food/dietary supplement for OSCC prevention. 3. Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells. 4. Alphitolic acid shows antimicrobial activity on Gram-positive bacteria and yeasts. 5. Alphitolic acid can inhibit NO release and iNOS expression in LPS-stimulated J774.A1 cultured macrophages. | |
| BCN1194 | Sanggenone D |
| 1. Sanggenones D, B, O,G show an antifungal activity with IC50 values between 10 and 123 microM. 2. Sanggenones(sanggenones C, D) represent a new scaffold of positive GABAA receptor modulators. 3. Sanggenones D, C and kazinol B inhibit COX-2 activity (ic 50 = 73-100 μM). 4. Sanggenone D has anti-inflammatory activity, it can inhibit NO production from lipopolysaccharide (LPS)-induced RAW 264.7 cells at > 10 uM; inhibition of nitric oxide production was mediated by suppression of iNOS enzyme induction but not by direct inhibition of iNOS enzyme activity. | |
| BCN1202 | Oroxin A |
| Oroxin A is a xanthine oxidase (XO) inhibitor, it exerts its antibreast cancer effects by inducing ER stress-mediated senescence, activating the key stress signaling pathway, and increasing key ER stress genes and expression levels. | |
| BCN1214 | 3-Isomangostin |
| 3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial activity with IC50 values in the range of 4.71-11.40 uM. | |
