Products with Vasocontraction bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1901 | Cocaine |
| 1. Cocaine is a powerfully addictive stimulant drug made from the leaves of the coca plant native to South America, it produces short-term euphoria. 2. Cocaine constricts blood vessels, dilates pupils, and increases body temperature, heart rate, and blood pressure. 3. Cocaine has a small number of accepted medical uses such as numbing and decreasing bleeding during nasal surgery. 4. Cocaine sensitizes VTA cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces Cocaine seeking. 5. Cocaine can cause headaches and gastrointestinal complications such as abdominal pain and nausea. Because cocaine tends to decrease appetite, chronic users can become malnourished as well. | |
| BCN2293 | Yohimbine |
| Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM. Yohimbine may augment extinction learning without significant side effects, and as a therapeutic augmentation strategy for exposure therapy in social anxiety disorder. Yohimbine can be used as antagonistic agents against medetomidine-induced diuresis in healthy cats; it inhibits ATP-sensitive K+ channels in mouse pancreatic beta-cells. | |
| BCN2310 | Dimethylacrylshikonin |
| Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors, it inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway. Dimethylacrylshikonin inhibits agonist-induced relaxation at lower concentrations and induces vasocontraction at higher concentrations. | |
| BCN4256 | 8-O-Acetylharpagide |
| 8-O-Acetylharpagide has anti-inflammatory, vasoconstrictor, antibacteria and antiviral activities, it also has a biological activity on isolated smooth muscle preparations from guinea pig. 8-O-Acetylharpagide presents the obvious inhibition on Epstein-Barr virus(EBV) infection, it not only apparently inhibits EBV-VCA,but also alleviates the hyperfunction and effusion of capillary permeability at the early inflammation. | |
| BCN6781 | Triptoquinone A |
| 1. Triptoquinone A has anti-inflammatory activity, it can significantly suppress smooth muscle relaxation and increase in cyclic GMP levels by nitric oxide (NO) in an L-arginine-induced relaxation experiment. 2. Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. 3. Triptoquinone A prevents ndotoxin-or interleukin-1 beta-promoted induction of nitric oxide synthase in vascular smooth muscle, thus inhibiting development of L-arginine-induced vasorelaxation. | |
