Natural Products from Ajuga ciliata
Natural Products Isolated from Ajuga ciliata
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- Natural product compounds selected from diverse chemical and biological sources.
- Broad structural diversity and coverage of biological activities.
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Natural Products from Ajuga ciliata
2 natural product s associated with Ajuga ciliata
| Catalog No. | Product Name | CAS Number | COA |
|---|---|---|---|
| BCN4256 |
8-O-Acetylharpagide
|
6926-14-3 | COA |
| BCN5416 |
Cyasterone
|
17086-76-9 | COA |
References
neo-Clerodane diterpenes from Ajuga ciliata Bunge and their neuroprotective activities.[Pubmed: 21807075]
Three new (1-3) and three known (4-6) neo-clerodane diterpenes have been isolated from the whole plants of Ajuga ciliata Bunge. The structures of the new compounds were elucidated as (12S)-1β,6α,19-triacetoxy-18-chloro-4α,12-dihydroxy-neo-clerod-13-en-15,16-olide (1), (12S,2'S)-12,19-diacetoxy-18-chloro-4α,6α-dihydroxy-1β-(2-methylbutanoyloxy)-neo-clerod-13-en-15,16-olide (2), and (12S)-6α,18,19-triacetoxy-4α,12-dihydroxy-1β-tigloyloxy-neo-clerod-13-en-15,16-olide (3), on the basis of spectroscopic data analysis. All the diterpenes were evaluated for the neuroprotective effects against MPP(+)-induced neuronal cell death in dopaminergic neuroblastoma SH-SY5Y cells and compounds 2-5 exhibited moderate neuroprotective effects.
Bioactive neo-clerodane diterpenoids from the whole plants of Ajuga ciliata Bunge.[Pubmed: 21682262]
Ten new neo-clerodane diterpenes, ajugaciliatins A-J (1-5, 8-12), along with 17 known analogues (6, 7, 13-27) were isolated from the whole plants of Ajuga ciliata Bunge. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the configuration of 1 was confirmed by X-ray crystallography. All of the compounds were assessed for neuroprotective effects against MPP(+)-induced neuronal cell death in dopaminergic neuroblastoma SH-SY5Y cells. Compounds 2, 6, 7, 9, 10, 15-17, 19, and 20 exhibited moderate neuroprotective effects.