Natural Products from Clausena dunniana
Natural Products Isolated from Clausena dunniana
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- Natural product compounds selected from diverse chemical and biological sources.
- Broad structural diversity and coverage of biological activities.
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Natural Products from Clausena dunniana
No products are currently associated with this botanical source.
References
Bioactive carbazole and quinoline alkaloids from Clausena dunniana.[Pubmed: 29625192]
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Carbazole alkaloids as new cell cycle inhibitor and apoptosis inducers from Clausena dunniana Levl.[Pubmed: 12450250]
Carbazole alkaloids, 3-methylcarbazole (1), murrayafoline A (2), girinimbine (3), mahanimbine (4) and bicyclomahanimbine (5), were isolated for the first time from Clausena dunniana Levl. by bioassay-guided separation procedure and were identified by spectroscopic methods. Compounds 1-5 showed growth inhibitory activity (1, IC50 25 microg/ml) on human fibrosarcoma HT-1080 cells and cell cycle M-phase inhibitory (2, MIC 0.78 microg/ml) and apoptosis inducing (2, MIC 1.56 microg/ml; 3, MIC 25 microg/ml; 4, MIC 20 microg/ml; 5, MIC 30 microg/ml) activities on mouse tsFT210 cells, respectively, and 2-5 provided the first examples of carbazole alkaloids as new cell cycle inhibitors and apoptosis inducers.
Two new ring A-rearranged clerodane diterpenes, dunniana acids A and B, from Clausena dunniana.[Pubmed: 11908988]
Two ring A-rearranged clerodane diterpenes named dunniana acids A (1) and B (2) were isolated from the aerial parts of Clausena dunniana. The structures of 1 and 2 were determined using spectral methods.