Clausena emarginata
Clausena emarginata
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Natural products/compounds from Clausena emarginata
- Cat.No. Product Name CAS Number COA
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BCN1001
Honokiol35354-74-6
Instructions
Carbazole alkaloids from Clausena emarginata with their potential antiproliferative activities.[Pubmed: 29772923]
None
Bioactive Coumarins from the Stems of Clausena emarginata.[Pubmed: 27450780]
None
Hepatoprotective pyranocoumarins from the stems of Clausena emarginata.[Pubmed: 27289140]
Seven pyranocoumarins, clauemarmarins A-G, along with 6 known analogues were isolated from the stems of Clausena emarginata. Their structures were elucidated by extensive spectroscopic analyses, and the absolute stereochemistries at C-6″ of clauemarmarin B, C and D and the absolute configurations of clauemarmarin E, F and G were determined by ECD experiments. Compounds clauemarmarin C, D and two known analogues exhibited hepatoprotective activities against DL-galactosamine-induced damage in WB-F344 cells at the concentration of 10 μM.
Limonoids with neuroprotective activity from the stems of Clausena emarginata.[Pubmed: 27268442]
Two new limonoids, clauemargines M-N (1-2), together with five known compounds (3-7), were isolated from the stems of Clausena emarginata, and compounds 6 and 7 were gained from this plant for the first time. Their structures were established and elucidated on the basis of comprehensive spectroscopic analysis. The absolute configurations of 1-2 were further determined by the octant rule of saturated cyclic ketone. Compounds 1, 2, 4, and 5 showed moderate neuroprotective effects against L-glutamic acid-induced cellular damage in human neuroblastoma SK-N-SH cells at 10 μM.
Clauemarazoles A-G, seven carbazole alkaloids from the stems of Clausena emarginata.[Pubmed: 25797535]
Seven new carbazole alkaloids, clauemarazoles A-G, together with 19 known analogues were isolated from the stems of Clausena emarginata. Their structures were established on the basis of spectroscopic analyses, and the absolute configurations of compounds 1a, 1b, 5a, and 5b were confirmed by their ECD spectroscopy. Compounds 4, 13, 15, and 17 exhibited inhibitory abilities on LPS-induced NO production. Compounds 10-12, 20, 22, and 24 displayed hepatoprotective effects against DL-galactosamine-induced damage in WB-F344 cells.
Anti-inflammatory amide alkaloids from the stems of Clausena emarginata.[Pubmed: 25248461]
Two new amide alkaloids, clauemaramide A (1) and clauemaramide B (2), and three known analogs were isolated from the stems of Clausena emarginata. Their structures were determined on the basis of spectroscopic analyses. The absolute configurations of 1 and 2 were confirmed by CD spectroscopy. Compound 3 showed moderate inhibitory effects on LPS-induced NO production (IC₅₉ value = 4.9 μM).
A,D-seco-limonoids from the stems of Clausena emarginata.[Pubmed: 24593150]
Twelve new A,D-seco-limonoids, clauemargines A-L (1-12), and three known analogues were isolated from the stems of Clausena emarginata. The absolute configurations of 1 and 5 were confirmed by X-ray crystallography and ECD spectroscopy, respectively. Compounds 1, 2, 8-10, and 13 showed moderate inhibitory effects on LPS-induced NO production (IC50 values<10 μM).
