Cytotoxic limonoids from the root bark of Dictamnus angustifolius.[Pubmed: 27601203]

Three novel limonoids, dictangustone G (1), dictangustone H (2), and dictangustone I (3) were isolated from the root bark of Dictamnus angustifolius. Their structures were elucidated on the basis of detailed spectroscopic analysis including UV, IR, HRESIMS, 1D and 2D NMR spectroscopic experiments. Compounds 1-3 were evaluated for their cytotoxic activities using Hela, A549, MCF7, and LN229 cell lines.

Medicinal uses, phytochemistry and pharmacology of the genus Dictamnus (Rutaceae).[Pubmed: 26068434]

Seven species from the genus Dictamnus are distributed throughout Europe and North Asia and only two species grow in China. One is Dictamnus dasycarpus Turcz., which could be found in many areas of China and has been recorded in Chinese Pharmacopoeia. The other is Dictamnus angustifolius G. Don ex Sweet, which is only present in Xinjiang province and has been used as an alternative for Dictamnus dasycarpus in the local for the treatment of rheumatism, bleeding, itching, jaundice, chronic hepatitis and skin diseases. The present paper reviewed the traditional uses, phytochemistry, pharmacology and toxicology of the genus Dictamnus.

Insight into reduction of obacunone, and their ester derivatives as insecticidal agents against Mythimna separata Walker.[Pubmed: 25465171]

Here we have prepared a series of ester compounds of obacunone, a naturally occurring limonoid, isolated from plants such as Citrus and Dictamnus angustifolius. Their insecticidal activity was evaluated at 1 mg/mL against the pre-third-instar larvae of oriental armyworm (Mythimna separata Walker), a typical lepidopteran pest. When obacunone reacted with NaBH₄, the ratio of two reduction products, C7α-hydroxyobacunone (2) and C7β-hydroxyobacunone (3), was related to the reaction mixing solvents. C7α-Propionyloxybacunone (4b) and C7β-(n)heptanoyloxybacunone (5g) exhibited the more promising insecticidal activity than their precursor obacunone and toosendanin.

Antimicrobial, antioxidant and cytotoxic properties of essential oil from Dictamnus angustifolius.[Pubmed: 24997390]

Dictamnus angustifolius (Rutaceae) has been used as an alternative for folk medicine, Dictamnus dasycarpus in the treatment of rheumatism, bleeding, itching, jaundice, chronic hepatitis, and skin diseases in Xinjiang Province of China. The aim of this study was to evaluate the antimicrobial and antioxidant activities of essential oil (EO) from Dictamnus angustifolius, correlated with their chemical composition and evaluate their cytotoxicity.

A new quinoline alkaloid from the roots of Dictamnus angustifolius.[Pubmed: 24702810]

To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae).

Degraded limonoids and quinoline alkaloids from Dictamnus angustifolius G. Don ex Sweet. and their anti-platelet aggregation activity.[Pubmed: 23948060]

A new degraded limonoid, named isodictamdiol A (1), two known degraded limonoids (2, 3) and a new nature product of quinoline alkaloid (4) along with five known quinoline alkaloids (5-9) were isolated from the root bark of Dictamnus angustifolius G. Don ex Sweet.. Certain useful NMR data were generalized to determine the structures of compounds 1 and 4. The structural elucidation of Compound 4 was first reported herein. Compounds 1-9 showed significant inhibitory effects on platelet aggregation induced by ADP at 250 μM, while Compound 4 showed potent anti-platelet aggregation activity.