Natural Products from Helleborus thibetanus
Natural Products Isolated from Helleborus thibetanus
BioCrick provides high-purity natural products and bioactive compounds isolated and purified from natural sources for scientific research.
- Natural product compounds selected from diverse chemical and biological sources.
- Broad structural diversity and coverage of biological activities.
- Product activity information can be supported by published literature, patents and research reports.
- Natural products can be selected according to source, target, activity and disease research interests.
- Compounds should be stored according to the product specifications after receipt.
Natural Products from Helleborus thibetanus
3 natural product s associated with Helleborus thibetanus
| Catalog No. | Product Name | CAS Number | COA |
|---|---|---|---|
| BCN2358 |
Gamabufotalin
|
465-11-2 | COA |
| BCN8857 |
Hellebrigenin
|
465-90-7 | COA |
| BCN2864 |
Vincetoxicoside B
|
22007-72-3 | COA |
References
New minor spirostanol glycosides from Helleborus thibetanus.[Pubmed: 27834098]
Phytochemical reinvestigation of the dried roots and rhizomes of Helleborus thibetanus afforded four new minor spirostanol glycosides (1-4) and four known spirostanol glycosides (5-8). Their structures were determined on the basis of spectroscopic analyses, including 1D and 2D NMR experiments, together with HR-ESI-MS and IR measurements and the results of acid hydrolysis.
Three new steroidal saponins from Helleborus thibetanus.[Pubmed: 26821553]
Three new steroidal saponins including two spirostanol glycosides (1-2) and one furostanol glycoside 1-sulphate (3) were isolated from the dried roots and rhizomes of Helleborus thibetanus. Structures of the compounds were determined on the basis of extensive use of 1-D and 2-D NMR experiments, together with HR-ESI-MS and IR measurements, as well as the results of acid hydrolysis. Compounds 1-2 represented steroidal saponins with an unusual substitution pattern, which possessed a double bond at C-25 and were glycosylated at 1-OH.
Two new bufadienolides from the rhizomes of Helleborus thibetanus with inhibitory activities against prostate cancer cells.[Pubmed: 24697315]
Two new bufadienolide glycosides (1 and 2) with an A/B trans ring fusion together with nine known compounds (3-11) were isolated from the rhizomes of Helleborus thibetanus. The structures of new compounds were elucidated by extensive spectroscopic analyses in combination with single-crystal X-ray diffraction. The bufadienolides 1 and 3-6 exhibited potent cytotoxic activities against the prostate cancer cells.
Two new bufadienolides from the rhizomes of Helleborus thibetanus Franch.[Pubmed: 20230875]
Two new bufadienolides, named tigencaoside A(1) and tigencaoside B(2), were isolated from the rhizomes of Helleborus thibetanus Franch., along with two known bufadienolides, hellebrigenin (3) and 5beta,14beta-dihydroxy-19-oxo-3beta-[(alpha-L-rhamnopyranosyl)oxy]bufa-20,22-dienolide (4). Their structures were elucidated on the basis of extensive spectroscopic analysis. Two new compounds were evaluated for their cytotoxic activities against four strains of cultured tumor cells.