Isodon rosthornii
Isodon rosthornii
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Natural products/compounds from Isodon rosthornii
- Cat.No. Product Name CAS Number COA
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BCN5953
Oridonin28957-04-2
Instructions
Bioactive ent-kaurane diterpenoids from Isodon rosthornii.[Pubmed: 23819871]
Isorosthin A (1), the first 20-nor-enmein-type diterpenoid, and 15 new ent-kauranoids, isorosthins B-P (2-16), along with 22 known analogues were isolated from the aerial parts of Isodon rosthornii. The structures of 1-16 were elucidated by means of spectroscopic analysis. The relative configuration of 2 and the absolute configuration of 3 were determined by single-crystal X-ray diffraction. Cytotoxicity evaluation against five human tumor lines showed inhibitory effects by several of the compounds tested. Furthermore, 12 of the isolates exhibited inhibitory activity against nitric oxide production in LPS-activated RAW264.7 macrophages.
ent-Atisane and ent-kaurane diterpenoids from Isodon rosthornii.[Pubmed: 23660245]
A new ent-atisanoid (1) and three new ent-kauranoids (2-4) belonging to different types, along with four known compounds were isolated from Isodon rosthornii. Their structures were established by means of extensive spectroscopic analysis. The absolute configuration of 1 was further determined by X-ray diffraction. Compounds 1 and 5 are the first example of atisane-type diterpenoid from this plant.
