InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1
Rotundine combined with methadone treatment may be a better therapeutic method in treatment of heroin dependence.[1]
Rhizoma Zingiberis(RZ), Flos Magnoliae(FM), and Fructus Litseae(FL), both have enhancing effect on Rotundine permeation.[2]
Rotundine injection can ameliorate the damages by modulating the activities of different types of NOS, and the various types of NOS play different roles in the lung damages after brain I/R injury at different stages in rats; rotundine provides remarkable protection against cerebral ischemia reperfusion damage, Its mechanisms may be through its influence on NO、ET 1 and energy metabolism.[3,4]
[1] Yong H U, Qiu Y, Zhong Y, et al.Chinese Journal of Drug Abuse Prevention & Treatment, 2006, 12(5):270-1.
[2] Cui L L, Yun-Shu M A, Han H X. Journal of Chinese Medicinal Materials, 2011, 34(5):753-7.
[3] Zeng A Y, Tu E Y, Han Z Y, et al. Metabolism, 2007, 30(2):111-8.
[4] Tang Y, Yang G. Journal of Emergenoy Medicine, 2000, 9(6):379-81.
[5] Feng M X. Chinese Journal of Pharmaceutical Analysis, 2008, 28(7):1180-3.
