(+)-Lyoniresinol

Catalog No.	BCN6248
CAS RN	14464-90-5
Molecular Weight	420.5
Molecular Formula	C22H28O8
Database	[PubChem]:382155983 [ChEBI]:68168 [PCIDB]:7205

Definition

Standard InChI

InChI=1S/C22H28O8/c1-27-15-7-12(8-16(28-2)20(15)25)18-14(10-24)13(9-23)5-11-6-17(29-3)21(26)22(30-4)19(11)18/h6-8,13-14,18,23-26H,5,9-10H2,1-4H3/t13-,14-,18+/m0/s1

Biological Activity

Lyoniresinol is one of the eight lignans purified from methanol extract of Vitex negundo and has robust tyrosinase inhibitory capacity, it decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulates MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression, it can perhaps be incorporated into clinical dermatologic use as a skin lightening agent. [1]
Lyoniresinol has antioxidative activity of pickled ume.[2]

Product information

English website: (+)-Lyoniresinol
Japanese website: (+)-Lyoniresinol
Chinese website: (+)-Lyoniresinol

References

[1] Liu H, Sui X, Li X, et al. Mol Cell Biochem, 2013, 373(1-2):211-6.
[2] Shirasaka N, Takasaki R, Yoshizumi H. West African J Med, 1994, 13(1):495-8.
[3] Chen Z Y, Ji-Jun W U, Liu X M, et al. Food Sci, 2009, 30(15):82-5.