InChI=1S/C19H18O4/c1-10-8-23-18-12-5-6-13-11(4-3-7-19(13,2)9-20)15(12)17(22)16(21)14(10)18/h5-6,8,20H,3-4,7,9H2,1-2H3/t19-/m1/s1

Tanshinone IIB (TSB) is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) widely used in the treatment of stroke and coronary heart disease in Asian countries; TSB significantly reduces the DNA laddering caused by staurosporine in a concentration-dependent manner, also suppresses the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons, indicates that TSB has a neuroprotective effect via inhibition of apoptosis.[1]
TSB significantly inhibits the uptake of digoxin and vinblastine in membrane vesicles containing PgP or MRP1, also moderately stimulates PgP ATPase activity, indicates that TSB is a substrate for PgP and MRP1 and that drug resistance to TSB therapy and drug interactions may occur through PgP and MRP1 modulation.[2]

English website: Tanshinone IIB
Japanese website: Tanshinone IIB
Chinese website: Tanshinone IIB

[1] Yu X Q, Xue C C, Zhou Z W, et al. Phytother Res, 2008, 22(6):846-50.
[2] Sarno C, Shestakofsky B, Shoemaker H, et al. Xenobiotica, 2007, 37(4):375-415.
[3] Hong Y, Zhu S, Huang Z H. CN 103819532 A [P] 2014.