An abietane diterpenoid that is abieta-8,11,13-triene substituted at position 18 by a carboxy group.
InChI=1S/C20H28O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h6,8,12-13,17H,5,7,9-11H2,1-4H3,(H,21,22)/t17-,19-,20-/m1/s1
Dehydroabietic acid (DHAA), a major poison to fishes in pulp and paper mill effluents, has toxicological and physiological effects, 20 μg l−1 is close to the “minimum effective concentration” of DHAA to rainbow trout.[1]
Dehydroabietic acid derivatives have been reported to display antisecretory and antipepsin effect in animal models, have gastroprotective activity in the HCl/EtOH-induced gastric lesions in mice as well as for cytotoxicity in human lung fibroblasts (MRC-5) and human epithelial gastric (AGS) cells. [2]
Dehydroabietic acid derivatives have antiulcer activity.[3]
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[1] Oikari A, Lönn B E, Castrén M, et al. Water Res, 1983, 17(1):81-9.
[2] Sepúlveda B, Astudillo L, Rodríguez J A, et al. Pharmacol Res, 2005, 52(5):429-37.
[3] Wada H, Kodato S, Kawamori M, et al. Chem Pharm Bull, 1985, 33(4):1472-87.
[4] K. Hroboňová, Dr. J. Lehotay, I. Skačáni, et al. J Liq Chromatogr R T, 2005, 28(11):1725-35.
