An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3β,5α,8α,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.
InChI=1S/C28H44O3/c1-18(2)19(3)7-8-20(4)22-9-10-23-25(22,5)13-12-24-26(6)14-11-21(29)17-27(26)15-16-28(23,24)31-30-27/h7-8,15-16,18-24,29H,9-14,17H2,1-6H3/b8-7+/t19-,20+,21-,22+,23+,24+,25+,26+,27+,28-/m0/s1
Ergosterol peroxide(EPO) is a major antitumor sterol produced by edible or medicinal mushrooms, the bacterial metabolites of EPO play a significant role in its cytotoxic activity against human colorectal cancer cells. [1]
Ergosterol peroxide can exert antitumor activity in multiple myeloma U266 cells partly with antiangiogenic activity targeting JAK2/ STAT3 signaling pathway as a potent cancer preventive agent for treatment of multiple myeloma cells.[2]
Ergosterol peroxide exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer.[3]
Ergosterol peroxide has antiviral action.[4]
Ergosterol peroxide can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to induce cancer cell death.[5]
English website: Ergosterol peroxide
Japanese website: Ergosterol peroxide
Chinese website: Ergosterol peroxide
[1] Lee J S, Ma C M, Park D K, et al. Biolo Pharm Bull, 2008, 31(5):949-54.
[2] Rhee Y H, Jeong S J, Lee H J, et al. Bmc Cancer, 2012, 12(1):1-11.
[3] Kang J H, Jang J E, Mishra S K, et al. J Ethnopharmacol, 2015, 173:303-12.
[4] Lindequist U, Lesnau A, Teuscher E, et al. Pharmazie, 1989, 44(44):579-80.
[5] Li X, Wu Q, Bu M, et al. Oncotarget, 2016.
[6] ZhangLi,Wang Y J, Ding A W, Jiangsu Traditional Chinese Medicine.2009(06):52-53.
