An amygdalin in which the stereocentre on the cyanohydrin function has R-configuration.
Amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax,suggests it may offer a valuable option for the treatment of prostate cancers.[1]
Amygdalin suppresses the prostaglandin E(2) synthesis and the nitric oxide production by inhibiting the LPS-stimulated mRNA expressions of COX-2 and iNOS in the mouse BV2 cells.[2]
Amygdalin can inhibit genes related to cell cycle in SNU-C4 human colon cancer cells.[3]
[1] Chang H K, Shin M S, Yang H Y, et al. Biol Pharm Bull, 2006, 29(8):1597-602.
[2] Yang H Y, Chang H K, Lee J W, et al. Neurol Res, 2013, 29 suppl 1(1):59-64(6).
[3] Park H J, Yoon S H, Han L S, et al. World J Gastroentero, 2005, 11(33):5156-61.
[4] Zhou C, Chen K, Sun C, et al. Biomed Chromatogr, 2007, 21(7):755-61.
