InChI=1S/C75H112O35/c1-30-44(81)48(85)53(90)63(99-30)107-59-58(105-43(80)17-12-33-10-13-34(97-9)14-11-33)32(3)101-67(60(59)108-64-56(93)51(88)57(31(2)100-64)106-62-52(89)47(84)40(28-98-62)104-65-54(91)49(86)45(82)38(26-76)102-65)110-69(96)74-21-20-70(4,5)24-36(74)35-15-16-41-71(6)25-37(79)61(109-66-55(92)50(87)46(83)39(27-77)103-66)73(8,68(94)95)42(71)18-19-72(41,7)75(35,29-78)23-22-74/h10-15,17,30-32,36-42,44-67,76-79,81-93H,16,18-29H2,1-9H3,(H,94,95)/b17-12+/t30-,31-,32+,36-,37-,38+,39+,40+,41+,42+,44-,45-,46+,47-,48+,49-,50-,51-,52+,53+,54+,55+,56+,57-,58-,59-,60+,61-,62-,63-,64-,65-,66-,67-,71+,72+,73-,74-,75-/m0/s1
Onjisaponin B, derived from Radix Polygalae, can enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.[1]
Onjisaponin B can reduce β-amyloid production and improve cognitive impairments, indicates that Onjisaponin B is effective against Alzheimer’s disease , providing a new therapeutic agent for further drug discovery.[2]
English website: Onjisaponin B
Japanese website: Onjisaponin B
Chinese website: Onjisaponin B
[1] Wu A G, Wong V K, Xu S W, et al. Int J Mol Sci, 2013, 14(11):22618-41.
[2] Li X, Cui J, Yu Y, et al. Plos One, 2016, 11(3): e0151147.
[3] Dou Z, Hu C M, Wen L, et al. Chinese journal of hospital pharmacy, 2014, 34 (19) : 1676-8.
