A ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the β-D-glucopyranoside group at position 20 is replaced by a β-D-glucopyranosyl-β-D-glucopyranoside group.
InChI=1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44+,45+,46?,47-,48-,49-,51-,52+,53+,54?/m0/s1
Ginsenosides, a class of ginseng compounds of herbal medicine, have therapeutic potential for the neuroprotection of brain damage after cerebral ischemia because of their anti-oxidant and anti-inflammation activities, ginsenoside Rb1 could represent promising applications as anti-oxidants for the anti-aging treatment of neurological disorders, such as stroke, in elderly patients.[1]
Ginsenoside Rb1 presents cardioprotective effect against I/R or H/R injury which involves in activating Akt, phosphorylating GSK-3β and inhibiting mPTP opening.[2]
Ginsenoside Rb1 has anti-oxidative effects on NPCs, may offer potential as a potent antioxidant for the treatment of neurological disorders.[3]
Ginsenoside Rb1 possesses protective effects on swimming exercise-induced oxidative stress in mice.[4]
Ginsenosides Rb1 and Rg1 have many molecular targets including the (CREB), which is involved in melanogenesis, they increase melanogenesis and activity in melanocytes by the activation of PKA/CREB/MITF Signaling.[5]
Ginsenoside Rb1, ginsenoside Rg1,and estrogen can significantly enhance OVA-specific IgG responses, lymphocyte proliferation and cytokines mRNA expression and the enhancement could be blocked by pre-injection of an estrogen receptor antagonist ICI 182780, indicating that ginsenoside Rb1, ginsenoside Rg1, and estrogen may exhibit the adjuvant activities through estrogen receptors.[6]
English website: Ginsenoside Rb1
Japanese website: Ginsenoside Rb1
Chinese website: Ginsenoside Rb1
[1] Xiao D, Lei Z, Lu S, et al. Geriatr Gerontol In, 2015,12(1).
[2] Yu-hong Li , Yan-yan Li , Guan-wei Fan, et al. Chin J Integr Med, 2016:1-10.
[3] Ye J, Yao J P, Wang X, et al. Mol Med Rep, 2016, 13(4):3083-91.
[4] Qi B, Zhang L, Zhang Z, et al. Pharmacogn Mag , 2014, 10(40):458-63.
[5] Lin M, Zhang B X, Zhang C, et al. Evid-Based Compl Al, 2014, 2014(14):892073.
[6] Li Y, Wu L, Yuan L, et al. American Journal of Traditional Chinese Veterinary Medicine, 2012,2(7):1-17.
[7] Li-Na J I, Feng W H, Wang Z M, et al. China journal of Chinese materia medica, 2013, 38(17):2798-802.
