Kaempferol

Catalog No. BCN5653
CAS RN 520-18-3
Molecular Weight 286.2
Molecular Formula C15H10O6
Database [PubChem]:382161930
[ChEBI]:28499
[PCIDB]:4565

Definition

A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.

Standard InChI

InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H

Biological Activity

Kaempferol is a polyphenol antioxidant found in fruits and vegetables, has beneficial effects in reducing the risk of chronic diseases, especially cancer, it may help to promote the development of cancer by augmenting the body's antioxidant defence against free radicals,and inhibit cancer cell growth and angiogenesis and induce cancer cell apoptosis.[1]
Kaempferol and quercetin have anti-inflammatory effects by modulating of iNOS, COX-2 and CRP, and involving blockade of NF-κB activation and the resultant up-regulation of the pro-inflammatory genes.[2]
Kaempferol is an autophagic enhancer, has a more general protection in Parkinson's disease, can mediate antiapoptotic and antioxidant effects is the enhancement of mitochondrial turnover by autophagy.[3]
Kaempferol and quercetin at concentrations ranging from 0.1 to 100 microM reduce bone resorption in a time and dose-dependent manner, have significant inhibitory effects at concentrations as low as 0.1 microM especially with kaempferol, they exert a potent inhibitory effect on in vitro bone resorption.[4]

Product information

English website: Kaempferol
Japanese website: Kaempferol
Chinese website: Kaempferol

References

[1] Chen A Y, Chen Y C.Food Chem, 2013, 138(4):2099-107.
[2] García-Mediavilla V, Crespo I, Collado P S, et al. Eur J Pharmacol, 2007, 557(2–3):221-9.
[3] Filomeni G, Graziani I, Zio D D, et al. Neurobiol  Aging, 2012, 33(4):767-85.
[4] Wattel A, Kamel S, Mentaverri R, et al. Biochem Pharmacol, 2003, 65(1):35-42.
[5] Yuanqing F U, Fengwei M O, Liao H. Medicinal Plant, 2013(1):42-43, 46.