A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1
Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis.[1]
Hesperetin has antioxidant activity, plays a protective role against 7,12-dimethylbenz(a)anthracene (DMBA)-induced oxidative stress; suppresses COX-2 gene expression may be a consequence of their antioxidant activity;is a powerful peroxynitrite (ONOO-)- scavenger and promotes cellular defense activity in the protection against ONOO- involved diseases.[2-4]
Hesperetin has inhibitory effects on Kv1.5 potassium channels stably expressed in HEK 293 cells and ultra-rapid delayed rectifier K + current in human atrial myocytes.[5]
Hesperetin,has antiplatelet activity, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity.[6]
Hesperetin mediates protection against doxorubicin-induced cardiotoxicity through nuclear factor-kappa B, p38, and caspase-3, indicates the protective effect of hesperetin against doxorubicin-induced cardiotoxicity.[7]
English website: Hesperetin
Japanese website: Hesperetin
Chinese website: Hesperetin
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[2] Choi E J. Life Sci, 2008, 82(21–22):1059-64.
[3] Kim J Y, Jung K J, Choi J S, et al. Free Radical Res, 2004, 38(7):761-9.
[4] Hirata A, Murakami Y, Shoji M, et al. Anticancer Res, 2005, 25(5):3367-74.
[5] Wang H, Wang H F, Chen W, et al. Eur J Pharmacol, 2016 ,789 :98-108.
[6] Jin Y R, Han X H, Zhang Y H, et al. Atherosclerosis, 2007, 194(1):144-52.
[7] Trivedi P P, Kushwaha S, Tripathi D N, et al. Cardiovasc Toxicol, 2011, 11(3):215-25.
[8] Wan L, Sun X, Xu Z, et al. China Pharmacist, 2010, 13(08):1082-4.
