8-O-acetyl shanzhiside methylester (ND01), an iridoid glucoside compound, was isolated from the leaves of Lamiophlomis rotata (Benth.) Kudo, ND01 has potential against cerebral ischemic injury, and its protective effect on oxygen–glucose deprivation-induced injury might be due to the suppression of intracellular Ca 2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.[1]
8- O -acetyl Shanzhiside Methylester can increases angiogenesis and improve functional recovery after stroke.[2]
8-O-acetyl shanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.[3]
8-O-acetyl shanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.[4]

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[1] Jiang W L, Fu F H, Zheng S G, et al. Eur J Pharmacol, 2010, 629(629):20-4.
[2] Jiang W L, Zhang S P, Zhu H B, et al. Basic Clin Pharmacol , 2011, 108(1):21-7.
[3] Kang Z C, Jiang W L, Xu Y, et al. Eur J Pharm Sci Official J Eur Federat Pharml Sci, 2012, 47(1):124-30.
[4] Zhang L, Kan Z C, Zhang X L, et al. Basic Clin Pharmacol , 2014, 115(6):481–7.
[5] Liao L D, Tang C, Sheng-Ming L U, et al. Res Practi on Chinese Med, 2011(05):70-2.