The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.
InChI=1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
Psoralen crosslinking between human immunodeficiency virus type 1 RNA and primer tRNA3(Lys).[1]
Psoralens and UVA light selectively inhibit binding to the higher-affinity EGF receptors, an effect analogous to that of the phorbol ester tumor promoters, since EGF is a growth-regulatory peptide, the ability of psoralens and UVA light to inhibit EGF binding may underlie the biologic effects of these agents in the skin.[2]
Psoralen induces DNA adducts are substrates for the base excision repair pathway in human cells.[3]
Psoralen induces a persistent intracellular DNA damage at a specific site and to afford prolonged transcription inhibition.[4]
[1] Skripkin E, Isel C, Marquet R, et al. Nucleic Acids Res, 1996, 24(3):509-14.
[2] Laskin J D, Lee E, Laskin D L, et al. P Natl Acad Sci U S A, 1986, 83(21):8211-5.
[3] Couvéprivat S, Macé G, Rosselli F, et al. Nucleic Acids Res, 2007, 35(17):5672-82.
[4] Guieysse A L, Praseuth D, Giovannangeli C, et al. J Mol Biol, 2000, 296(2):373-83.
[5] Sawut N, Yang Y U, Halik S. Modern Chinese Med, 2012, 14(10):16-19.
