Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC3745 | Carbenoxolone disodium |
| Glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. | |
| BCC3755 | Clotrimazole |
| Imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR). | |
| BCC3759 | Cytarabine |
| Nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent. | |
| BCC3776 | Epleremone |
| Selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo. | |
| BCC3781 | Flurbiprofen |
| Potent inhibitor of cyclooxygenase (IC50 values are 0.1 and 0.4 μM for inhibition of human COX-1 and COX-2 respectively). Analgesic, anti-inflammatory and antipyretic in vivo. Inhibits tumor cell growth in vitro and in vivo. Regulates prostate stem cell antigen through activation of Akt kinase. Also inhibits fibroblast proliferation in vitro. | |
| BCC3782 | Furosemide |
| Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors. | |
| BCC3790 | GW3965 HCl |
| Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXRα and hLXRβ (EC50 values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis. | |
| BCC3799 | Nilvadipine |
| Syk inhibitor. Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model. Also L-type calcium channel blocker and antihypertensive. | |
