Resveratrol glycosides were found to reduce postprandial blood glucose in the northwest plateau of Chinese academy of sciences
Through systematic isolation and screening of the chemical components in tanggut yellow, the northwest institute of plateau biology, Chinese academy of sciences, found that resveratrol glycosides had significant down-glucosidase inhibitory activity, which could significantly inhibit the increase of postmeal blood glucose in diabetic mice. The study offers alternative compounds for the development of treatments for postprandial hyperglycemia in diabetes. The paper was published recently in the Journal of Agricultural and Food Chemistry.
Diabetes is a chronic metabolic disease characterized by hyperglycemia and serious diabetic complications, including coronary artery disease, stroke, peripheral artery disease, retinopathy, kidney disease and neuropathy, said zhou guoying, a researcher at the northwest plateau institute of the Chinese academy of sciences and the corresponding author of the paper. Regulating postprandial blood glucose level is an effective treatment for diabetes and prevention of diabetes-related complications. A-glucosidase inhibitors have been recommended as first-line drugs for the treatment of diabetes, but their adverse effects on the gastrointestinal tract have limited clinical significance. Therefore, it is a research hotspot in this field to screen effective and low toxicity grape glucosidase inhibitors from natural products.
Zhao xiaohui, associate researcher at the northwest plateau institute of the Chinese academy of sciences and the first author of the paper, said that through the systematic isolation and screening of the chemical components in tangguodong, the research group on vegetation restoration and medicinal plant resources of the institute found that resveratrol glycosides had significant gs-glucosidase inhibitory activity. In vivo studies showed that oral administration of resveratrol glycosides significantly inhibited the increase of postprandial glucose in normal and diabetic mice in a dose-dependent manner. In addition, the competitive inhibition mechanism of resveratrol glucosidase was determined by enzyme kinetics analysis and molecular docking experiments. The research was supported by qinghai international cooperation project, qinghai natural fund project and sichuan provincial cooperation project
