Traditional herbal compound relieves inflammatory and neuropathic pain
Natural chemicals from plant relieves inflammation and pain
According to pharmacology researchers at the University of California, Irvine, a compound extracted from traditional Chinese herbal medicine can effectively relieve pain, pointing out a new nonaddictive analgesic method for acute inflammation and nerve pain.
California State Owen, Jun 4, 2018--according to pharmacology at the University of California, Irvine, compounds extracted from traditional Chinese herbal medicines are effective in alleviating pain, pointing to a new nonaddictive analgesic method for acute inflammation and neurological pain. Researchers.
With a Chinese scientist, Oliver Civelli and his colleagues at the University of California, Irvine, have isolated a compound called dehydrocorybulbine (DHCB) from the roots of the purple pansy plant. In rodents trials, DHCB has been shown to reduce inflammatory pain, which is associated with tissue damage, immune cell infiltration, and injury-induced neuropathic pain, which is caused by neurological damage.
This is important because there is not enough treatment for neuropathic pain. In addition, the researchers found that DHCB did not produce tolerance and continued to use most conventional painkillers, such as morphine.
"Today the pharmaceutical industry is trying to find new drugs. However, over the centuries, herbal remedies have been used to address countless health conditions, including pain. Our goal is to identify the compounds in these herbal therapies that can help us find new ways to treat health problems, "Civelli said," Eric L. Nelson chairs in neuroscience. "We are very excited, which shows promise as an effective drug."
It also shows a different way to understand the pain mechanism.The results of the study appeared on the January 20 issue of biology.
They are the product of cooperation between the two groups separated by the Pacific Ocean. With the greater acceptance of traditional Chinese medicine in Western medicine practice, Xinmiao and his team of the Dalian Institute of Chemical Physics in China have been working to create the "herbalome" of all compounds in plant extracts, showing pharmacological properties.
The University of California, Irvine Group recommends the application of "reverse pharmacology"-a new Drug discovery method--herbalome project designed by Civelli 25 years ago. Together, they screened 10 Chinese herbs, known as painkillers, and tested the pain-relieving ability of nearly 500 drugs. Only DHCB induce the recurrence effect in the Corydalis.
The purple pansy is a flowering herb growing in Siberia, northern China and Japan. People use their root extracts to relieve menstrual cramps, chest pain and abdominal pain.
This was previously studied in the analgesic nature, but this is the first time DHCB has been found, extracted and tested. Chronic neuropathic pain affects more than 50 million Americans, however, the management of this pain is still a major clinical challenge due to the adverse results of traditional analgesics and serious side effects.
Civelli said the use of traditional Chinese herbal products could lead to breakthrough treatment for these patients. DHCB need to evaluate any toxicity in order to develop it as a drug. It is also possible that if the compound is chemically modified, a more effective drug can be found. Although DHCB is not currently available, it is part of a Hussogen or extract that can be purchased in a health shop or online.
