What is the underlying cause lead to diabetes

Type II diabetes pathogensis

Diabetes mellitus type II,also known as type II diabetes is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin,affecting almost 400 million people around the world.The traditional hypothesis for its pathogenesis is that obesity leads to hyperglycemia and insulin resistance, resulting in compensatory hyperinsulinemia and, eventually, the diabetic phenotype. However, this hypothesis does not explicate a crowd of curious phenomena, such as why some obese people have hyperinsulinemia without hyperglycemia or insulin resistance. In addition, studies show that hyperinsulinemia can cause insulin resistance; In this case, Which is the underlying cause in the development of diabetes: insulin resistance or hyperinsulinemia.

Being the older concept of the two, the