(20R)-ProtopanaxdiolCAS# 7755-01-3 |
- (20S)-Protopanaxdiol
Catalog No.:BCN1254
CAS No.:30636-90-9
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 7755-01-3 | SDF | Download SDF |
PubChem ID | 3080644 | Appearance | White powder |
Formula | C30H52O3 | M.Wt | 460.74 |
Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | (3S,8R,9R,10R,12R,13R,14S,17S)-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol | ||
SMILES | CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)O)C)C)O)C)O)C | ||
Standard InChIKey | PYXFVCFISTUSOO-OIORDRSNSA-N | ||
Standard InChI | InChI=1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22?,23+,24-,25-,27-,28+,29-,30+/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Protopanaxdiol is effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet, it inhibits tumor interstitial microvascular density and its proliferation activity, finally inhibits tumor growth, it also inhibits expression of VEGF and bFGF protein. (20R)-Protopanaxdiol has protective effect on myocardial ischemia, which may be related to improving free radicals metabolism and myocardial metabolism, decreasing plasma TXA 2 levels. |
Targets | p38MAPK | JNK | VEGFR | bFGF | ATF2 |
In vitro | Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet.[Pubmed: 20627120]Fitoterapia. 2010 Dec;81(8):1079-87.Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. |
In vivo | Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions.[Pubmed: 25535478]J Ginseng Res. 2015 Jan;39(1):61-8Korean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and anti-inflammatory activities. Only a few studies have explored the molecular mechanism of KRG-mediated anti-inflammatory activity.
Antimyocardial ischemic effects of Panax quinquefolium 20s-protopanaxdiol saponins (PQDS) and its mechanism[Reference: WebLink]Journal of Chinese Pharmaceutical Sciences, 2002, 37(2):100-3.To study the antimyocardial ischemic effects of Panax quinquefolium 20 s-protopanaxdiolsaponins (PQDS) extracted from the leaves of Panax quinquefolium and its mechanism. |
Animal Research | Influences of Protopanaxdiol to vascular endothelial growth factor and basofibroblast growth factor protein expression of liver[Reference: WebLink]Chinese Journal of Clinical Hepatology, 2008, 24(1):42-3. To discuss influences of Protopanaxdiol to vascular endothelial growth factor and basofibroblast growth factor protein expression of liver. |
(20R)-Protopanaxdiol Dilution Calculator
(20R)-Protopanaxdiol Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.1704 mL | 10.8521 mL | 21.7042 mL | 43.4084 mL | 54.2605 mL |
5 mM | 0.4341 mL | 2.1704 mL | 4.3408 mL | 8.6817 mL | 10.8521 mL |
10 mM | 0.217 mL | 1.0852 mL | 2.1704 mL | 4.3408 mL | 5.4261 mL |
50 mM | 0.0434 mL | 0.217 mL | 0.4341 mL | 0.8682 mL | 1.0852 mL |
100 mM | 0.0217 mL | 0.1085 mL | 0.217 mL | 0.4341 mL | 0.5426 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Corylifol C
Catalog No.:BCN3200
CAS No.:775351-91-2
- Corylifol B
Catalog No.:BCN3199
CAS No.:775351-90-1
- Corylifol A
Catalog No.:BCN3198
CAS No.:775351-88-7
- Imeglimin
Catalog No.:BCC4221
CAS No.:775351-65-0
- Imeglimin hydrochloride
Catalog No.:BCC4085
CAS No.:775351-61-6
- PTC124 (Ataluren)
Catalog No.:BCC3881
CAS No.:775304-57-9
- DL-m-Tyrosine
Catalog No.:BCC3332
CAS No.:775-06-4
- Phenylpiracetam
Catalog No.:BCC1859
CAS No.:77472-70-9
- Pimobendan hydrochloride
Catalog No.:BCC4175
CAS No.:77469-98-8
- KM 11060
Catalog No.:BCC7578
CAS No.:774549-97-2
- 5-Androsten-3β-ol-17-one ethyleneketal
Catalog No.:BCC8738
CAS No.:7745-40-6
- Episesartemin A
Catalog No.:BCN7239
CAS No.:77449-31-1
- Ingenol-5,20-acetonide
Catalog No.:BCN2960
CAS No.:77573-43-4
- Ingenol-3,4:5,20-diacetonide
Catalog No.:BCN2959
CAS No.:77573-44-5
- Nestoron
Catalog No.:BCC1797
CAS No.:7759-35-5
- Isoscopoletin
Catalog No.:BCN4582
CAS No.:776-86-3
- Fmoc-HomoArg-OH
Catalog No.:BCC2645
CAS No.:776277-76-0
- 1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone
Catalog No.:BCN1358
CAS No.:776325-66-7
- Toddanone
Catalog No.:BCN3430
CAS No.:77636-08-9
- Boc-D-Ala-OH
Catalog No.:BCC3049
CAS No.:7764-95-6
- Pterokaurene L3
Catalog No.:BCN4583
CAS No.:77658-38-9
- ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid
Catalog No.:BCN1357
CAS No.:77658-39-0
- ent-9-Hydroxy-15-oxo-19-kauranoic acid
Catalog No.:BCN1356
CAS No.:77658-45-8
- ent-11,16-Epoxy-15-hydroxykauran-19-oic acid
Catalog No.:BCN1355
CAS No.:77658-46-9
Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet.[Pubmed:20627120]
Fitoterapia. 2010 Dec;81(8):1079-87.
Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrolysis of about 83.2% of triolein at about 1mg/ml of PDG. However, PTG showed no inhibitory activity. Therefore, anti-obesity activity of PDG was evaluated in mice fed a high-fat diet. The results demonstrated that PDG was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet.
Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions.[Pubmed:25535478]
J Ginseng Res. 2015 Jan;39(1):61-8.
BACKGROUND: Korean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and anti-inflammatory activities. Only a few studies have explored the molecular mechanism of KRG-mediated anti-inflammatory activity. METHODS: We investigated the anti-inflammatory mechanisms of the protopanaxadiol saponin fraction (PPD-SF) of KRG using in vitro and in vivo inflammatory models. RESULTS: PPD-SF dose-dependently diminished the release of inflammatory mediators [nitric oxide (NO), tumor necrosis factor-alpha, and prostaglandin E2], and downregulated the mRNA expression of their corresponding genes (inducible NO synthase, tumor necrosis factor-alpha, and cyclooxygenase-2), without altering cell viability. The PPD-SF-mediated suppression of these events appeared to be regulated by a blockade of p38, c-Jun N-terminal kinase (JNK), and TANK (TRAF family member-associated NF-kappa-B activator)-binding kinase 1 (TBK1), which are linked to the activation of activating transcription factor 2 (ATF2) and interferon regulatory transcription factor 3 (IRF3). Moreover, this fraction also ameliorated HCl/ethanol/-induced gastritis via suppression of phospho-JNK2 levels. CONCLUSION: These results strongly suggest that the anti-inflammatory action of PPD-SF could be mediated by a reduction in the activation of p38-, JNK2-, and TANK-binding-kinase-1-linked pathways and their corresponding transcription factors (ATF2 and IRF3).