Chimonanthine

CAS# 5545-89-1

Chimonanthine

Catalog No. BCN7824----Order now to get a substantial discount!

Product Name & Size Price Stock
Chimonanthine: 5mg $265 In Stock
Chimonanthine: 10mg Please Inquire In Stock
Chimonanthine: 20mg Please Inquire Please Inquire
Chimonanthine: 50mg Please Inquire Please Inquire
Chimonanthine: 100mg Please Inquire Please Inquire
Chimonanthine: 200mg Please Inquire Please Inquire
Chimonanthine: 500mg Please Inquire Please Inquire
Chimonanthine: 1000mg Please Inquire Please Inquire

Quality Control of Chimonanthine

Number of papers citing our products

Chemical structure

Chimonanthine

3D structure

Chemical Properties of Chimonanthine

Cas No. 5545-89-1 SDF Download SDF
PubChem ID 3083909 Appearance Powder
Formula C22H26N4 M.Wt 346.48
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3aS,8bS)-8b-[(3aS,8bS)-3-methyl-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-8b-yl]-3-methyl-1,2,3a,4-tetrahydropyrrolo[2,3-b]indole
SMILES CN1CCC2(C1NC3=CC=CC=C32)C45CCN(C4NC6=CC=CC=C56)C
Standard InChIKey HOYXPMHLHJOGHD-FNAHDJPLSA-N
Standard InChI InChI=1S/C22H26N4/c1-25-13-11-21(15-7-3-5-9-17(15)23-19(21)25)22-12-14-26(2)20(22)24-18-10-6-4-8-16(18)22/h3-10,19-20,23-24H,11-14H2,1-2H3/t19-,20-,21+,22+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Chimonanthine

The flower buds of Chimonanthus praecox

Biological Activity of Chimonanthine

Description1. (-)-Chimonanthine (IC50 = 0.93 uM) shows potent inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.

Chimonanthine Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Chimonanthine Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Chimonanthine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8862 mL 14.4308 mL 28.8617 mL 57.7234 mL 72.1542 mL
5 mM 0.5772 mL 2.8862 mL 5.7723 mL 11.5447 mL 14.4308 mL
10 mM 0.2886 mL 1.4431 mL 2.8862 mL 5.7723 mL 7.2154 mL
50 mM 0.0577 mL 0.2886 mL 0.5772 mL 1.1545 mL 1.4431 mL
100 mM 0.0289 mL 0.1443 mL 0.2886 mL 0.5772 mL 0.7215 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Chimonanthine

Dimeric pyrrolidinoindoline-type alkaloids with melanogenesis inhibitory activity in flower buds of Chimonanthus praecox.[Pubmed:24668298]

J Nat Med. 2014 Jul;68(3):539-49.

A methanol extract of the flower buds of Chimonanthus praecox (L.) Link (Calycanthaceae) demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From the extract, five dimeric pyrrolidinoindoline alkaloids and four sesquiterpenes were isolated, together with 16 known compounds. Among them, (-)-Chimonanthine (1, IC50 = 0.93 muM), (-)-folicanthine (2, 1.4 muM), and (-)-calycanthidine (3, 1.8 muM) showed potent inhibitory effects without notable cytotoxicity at the effective concentrations. The most potent alkaloid (1) inhibited both tyrosinase and tyrosine-related protein-1 mRNA expressions, to which the melanogenesis inhibitory activity would be ascribable.

Description

Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis.

Keywords:

Chimonanthine,5545-89-1,Natural Products, buy Chimonanthine , Chimonanthine supplier , purchase Chimonanthine , Chimonanthine cost , Chimonanthine manufacturer , order Chimonanthine , high purity Chimonanthine

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: