Cobimetinib (racemate)Selective MEK inhibitor CAS# 934662-91-6 |
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Quality Control & MSDS
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| Cas No. | 934662-91-6 | SDF | Download SDF |
| PubChem ID | 51038893 | Appearance | Powder |
| Formula | C21H21F3IN3O2 | M.Wt | 531.31 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | GDC-0973 racemate; XL518 | ||
| Solubility | DMSO : ≥ 40 mg/mL (75.29 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-(3-hydroxy-3-piperidin-2-ylazetidin-1-yl)methanone | ||
| SMILES | C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O | ||
| Standard InChIKey | BSMCAPRUBJMWDF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Cobimetinib racemate is the less active racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor. References: | |||||
Cobimetinib (racemate) Dilution Calculator
Cobimetinib (racemate) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.8821 mL | 9.4107 mL | 18.8214 mL | 37.6428 mL | 47.0535 mL |
| 5 mM | 0.3764 mL | 1.8821 mL | 3.7643 mL | 7.5286 mL | 9.4107 mL |
| 10 mM | 0.1882 mL | 0.9411 mL | 1.8821 mL | 3.7643 mL | 4.7054 mL |
| 50 mM | 0.0376 mL | 0.1882 mL | 0.3764 mL | 0.7529 mL | 0.9411 mL |
| 100 mM | 0.0188 mL | 0.0941 mL | 0.1882 mL | 0.3764 mL | 0.4705 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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GDC-0973(XL-518; GDC 0973) is a selective inhibitor of MEK. GDC-0973 is also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.
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Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.
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