Cyclocarioside ICAS# 1644624-82-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 1644624-82-7 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C35H56O8 | M.Wt | 604.91 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Cyclocarioside I Dilution Calculator
Cyclocarioside I Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.6531 mL | 8.2657 mL | 16.5314 mL | 33.0628 mL | 41.3285 mL |
| 5 mM | 0.3306 mL | 1.6531 mL | 3.3063 mL | 6.6126 mL | 8.2657 mL |
| 10 mM | 0.1653 mL | 0.8266 mL | 1.6531 mL | 3.3063 mL | 4.1328 mL |
| 50 mM | 0.0331 mL | 0.1653 mL | 0.3306 mL | 0.6613 mL | 0.8266 mL |
| 100 mM | 0.0165 mL | 0.0827 mL | 0.1653 mL | 0.3306 mL | 0.4133 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Screening and identification of alpha-glucosidase inhibitors from Cyclocarya paliurus leaves by ultrafiltration coupled with liquid chromatography-mass spectrometry and molecular docking.[Pubmed:35635870]
J Chromatogr A. 2022 Jul 19;1675:463160.
Cyclocarya paliurus, as an important edible and medicinal product, has shown a good prospect in the prevention of diabetes mellitus (DM). However, it is unclear which active compounds derived from C. paliurus play a significant role in inhibiting alpha-glucosidase activity. In present study, affinity-based screening assay was developed to screen and identify potential alpha-glucosidase inhibitors from C. paliurus leaves based on affinity ultrafiltration coupled with ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) and molecular docking. After being enriched by D-101 macroporous resin, five eluent fractions with different polarity were obtained and their inhibitory activities on alpha-glucosidase were evaluated by an enzyme inhibition assay in vitro. The result showed that 70% ethanol fraction of C. paliurus leaves exhibited remarkable alpha-glucosidase inhibitory activity with the IC(50) value of 17.81 microg/mL. The 70% ethanol fraction was incubated with alpha-glucosidase and then active compounds would form enzyme-inhibitor complexes. The complexes could be separated from inactive components by the interception ability of ultrafiltration membrane under centrifugation. A total of 36 active compounds were screened from C. paliurus leaves and the chemical structures were further characterized by UPLC-QTOF-MS/MS. Furthermore, molecular docking was performed to investigate possible inhibitory mechanisms between active compounds and alpha-glucosidase. The docking result showed that Cyclocarioside I, pterocaryoside B, arjunolic acid, cyclocarioside Z5, cypaliuruside D and cyclocarioside N could be embedded well into the active pocket of alpha-glucosidase, and had significant affinity interactions with critical amino acid residues by forming hydrogen bonds, hydrophobic interactions and van der Waals, and affinity energies ranged from -9.3 to -6.7 kJ/mol. The results indicated that the developed method is rapid and effective for high throughput screening of potential alpha-glucosidase inhibitors from complex mixtures. Moreover, C. paliurus exhibited a remarkable inhibitory activity on alpha-glucosidase, making it a promising candidate for the prevention of DM.
Cyclocariosides II and III: two secodammarane triterpenoid saponins from Cyclocarya paliurus.[Pubmed:8824950]
Planta Med. 1995 Dec;61(6):551-3.
Two new secodammarane triterpenoid saponins were isolated from the leaves of Cyclocarya paliurus. Based on chemical and spectral analysis they were assigned as (20S)-20-hydroxy-24-O-alpha-L-arabino-pyranosyl-3,4- secodammar-4(28),11,25-trien-3-oic acid, named Cyclocarioside II and 25-hydroxy-(20S,24R)-epoxy-12R-O-beta-D- quinovopyranosyl-3,4-secodammar-4(28)-en,3-oic acid, named Cyclocarioside III.
