Taccabulin A

CAS# 1464719-37-6

Taccabulin A

Catalog No. BCX0599----Order now to get a substantial discount!

Product Name & Size Price Stock
Taccabulin A: 5mg $914 In Stock
Taccabulin A: 10mg Please Inquire In Stock
Taccabulin A: 20mg Please Inquire Please Inquire
Taccabulin A: 50mg Please Inquire Please Inquire
Taccabulin A: 100mg Please Inquire Please Inquire
Taccabulin A: 200mg Please Inquire Please Inquire
Taccabulin A: 500mg Please Inquire Please Inquire
Taccabulin A: 1000mg Please Inquire Please Inquire

Quality Control of Taccabulin A

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Chemical structure

Taccabulin A

Chemical Properties of Taccabulin A

Cas No. 1464719-37-6 SDF Download SDF
PubChem ID N/A Appearance Powder
Formula C19H22O6 M.Wt 346.41
Type of Compound Chalcones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Taccabulin A Dilution Calculator

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Taccabulin A Molarity Calculator

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Preparing Stock Solutions of Taccabulin A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8868 mL 14.4338 mL 28.8675 mL 57.7351 mL 72.1688 mL
5 mM 0.5774 mL 2.8868 mL 5.7735 mL 11.547 mL 14.4338 mL
10 mM 0.2887 mL 1.4434 mL 2.8868 mL 5.7735 mL 7.2169 mL
50 mM 0.0577 mL 0.2887 mL 0.5774 mL 1.1547 mL 1.4434 mL
100 mM 0.0289 mL 0.1443 mL 0.2887 mL 0.5774 mL 0.7217 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Taccabulin A

Structure-activity relationships of retro-dihydrochalcones isolated from Tacca sp.[Pubmed:24303844]

J Nat Prod. 2013 Dec 27;76(12):2189-94.

Several biologically active compounds have been identified from Tacca species, including glycosides, diarylheptanoids, saponins, withanolides, and the taccalonolide class of microtubule stabilizers. More recently, two cytotoxic retro-dihydrochalcones named evelynin A (7) and Taccabulin A (6) were isolated and their biological activities characterized, including the finding that taccabulin has microtubule destabilizing effects. Here we describe the identification and characterization of five new retro-chalcones, named taccabulins B-E (1-4) and evelynin B (5) from Tacca sp. extracts. Their structures were determined using 1D and 2D NMR as well as mass spectroscopic data and modeled into the colchicine binding site of tubulin. The antiproliferative and microtubule effects of each compound were determined experimentally and found to be well correlated with modeling studies. The isolation and biological characterization of several retro-dihydrochalcones facilitated preliminary structure-activity relationships for this compound class concerning its antiproliferative and microtubule depolymerizing activities.

The bat flower: a source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions.[Pubmed:24087857]

J Nat Prod. 2013 Oct 25;76(10):1923-9.

The biosynthesis of secondary metabolites provides higher plants with mechanisms of defense against microbes, insects, and herbivores. One common cellular target of these molecules is the highly conserved microtubule cytoskeleton, and microtubule-targeting compounds with insecticidal, antifungal, nematicidal, and anticancer activities have been identified from plants. A new retro-dihydrochalcone, Taccabulin A, with microtubule-destabilizing activity has been identified from the roots and rhizomes of Tacca species. This finding is notable because the microtubule-stabilizing taccalonolides are also isolated from these sources. This is the first report of an organism producing compounds with both microtubule-stabilizing and -destabilizing activities. A two-step chemical synthesis of Taccabulin A was performed. Mechanistic studies showed that Taccabulin A binds within the colchicine site on tubulin and has synergistic antiproliferative effects against cancer cells when combined with a taccalonolide, which binds to a different site on tubulin. Taccabulin A is effective in cells that are resistant to many other plant-derived compounds. The discovery of a natural source that contains both microtubule-stabilizing and -destabilizing small molecules is unprecedented and suggests that the synergistic action of these compounds was exploited by nature long before it was discovered in the laboratory.

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