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Gambogic acid A

CAS# 1592842-93-7

Gambogic acid A

2D Structure

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Product Name & Size Price Stock
Gambogic acid A: 5mg $357 In Stock
Gambogic acid A: 10mg Please Inquire In Stock
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Gambogic acid A

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Chemical Properties of Gambogic acid A

Cas No. 1592842-93-7 SDF Download SDF
PubChem ID N/A Appearance Powder
Formula C39H48O10 M.Wt 676.8
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Gambogic acid A

The herbs of Garcinia hanburyi Hook. f.

Gambogic acid A Dilution Calculator

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Gambogic acid A Molarity Calculator

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Preparing Stock Solutions of Gambogic acid A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4775 mL 7.3877 mL 14.7754 mL 29.5508 mL 36.9385 mL
5 mM 0.2955 mL 1.4775 mL 2.9551 mL 5.9102 mL 7.3877 mL
10 mM 0.1478 mL 0.7388 mL 1.4775 mL 2.9551 mL 3.6939 mL
50 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.591 mL 0.7388 mL
100 mM 0.0148 mL 0.0739 mL 0.1478 mL 0.2955 mL 0.3694 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Gambogic acid A

Gambogic Acid and Piperine Synergistically Induce Apoptosis in Human Cholangiocarcinoma Cell via Caspase and Mitochondria-Mediated Pathway.[Pubmed:35600948]

Evid Based Complement Alternat Med. 2022 May 12;2022:6288742.

Most cholangiocarcinoma (CCA) patients undergo chemotherapy as a therapeutic approach due to the disease's frequently late diagnosis. However, because CCA is resistant to currently available treatments, the prognosis for this cancer is still quite poor. Combination therapy has emerged as a novel and promising strategy in cancer treatment, as monotherapy frequently results in tumor recurrence and drug resistance. Gambogic acid has been shown to have a synergism with other compounds in combating certain cancer cells. Moreover, piperine has been shown to improve the efficacy of numerous chemotherapy drugs and other anticancer natural substances. However, no research has been done on the combination of these two compounds in the treatment of bile duct cancer. In this study, the cytotoxic activity was determined by using the MTT assay, and then, the combined effect was assessed by using the combination index (CI). We found that the combination of Gambogic acid And piperine inhibited cell viability more effectively than either treatment alone, and it also demonstrated a synergistically cytotoxic effect against CCA cells. Interestingly, the findings allowed the use of lower concentrations of gambogic acid in cancer treatment when combined with piperine, which could reduce its adverse effect on normal cholangiocytes. Furthermore, the combination of the two compounds increased CCA cell death by inducing apoptosis via both the extrinsic and intrinsic or mitochondria-mediated pathways, as determined by caspase-3, -8, and -9 activity and the reduction of mitochondrial transmembrane potential (DeltaPsim). It is possible that the use of these two natural compounds together could be a promising strategy for the treatment of bile duct cancer.

Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs.[Pubmed:35566290]

Molecules. 2022 May 4;27(9). pii: molecules27092937.

Gambogic acid (GA) is a natural product with a wide range of pharmacological properties. It plays an important role in inhibiting tumor growth. A large number of GA derivatives have been designed and prepared to improve its shortcomings, such as poor water solubility, low bioavailability, poor stability, and adverse drug effects. So far, GA has been utilized to develop a variety of active derivatives with improved water solubility and bioavailability through structural modification. This article summarized the progress in pharmaceutical chemistry of GA derivatives to provide a reference and basis for further study on structural modifications of GA and expansion of its clinical applications.

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