Gnetuhainin ICAS# 308105-06-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 308105-06-8 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C30H28O9 | M.Wt | 532.58 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Gnetuhainin I Dilution Calculator
Gnetuhainin I Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.8777 mL | 9.3883 mL | 18.7765 mL | 37.553 mL | 46.9413 mL |
| 5 mM | 0.3755 mL | 1.8777 mL | 3.7553 mL | 7.5106 mL | 9.3883 mL |
| 10 mM | 0.1878 mL | 0.9388 mL | 1.8777 mL | 3.7553 mL | 4.6941 mL |
| 50 mM | 0.0376 mL | 0.1878 mL | 0.3755 mL | 0.7511 mL | 0.9388 mL |
| 100 mM | 0.0188 mL | 0.0939 mL | 0.1878 mL | 0.3755 mL | 0.4694 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Identification of lignans as ATP citrate lyase (ACLY) inhibitors from the roots of Pouzolzia zeylanica.[Pubmed:37265118]
Nat Prod Res. 2024 May;38(10):1719-1726.
A new lignan, named pouzolignan P (1), together with 14 known ones (2 - 15) were isolated from the roots of Pouzolzia zeylanica (L.) Benn. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates were evaluated for their inhibitory activities toward the ATP citrate lyase (ACLY). Among them, four lignans, isopouzolignan K (3), gnemontanins E (5), Gnetuhainin I (6), and styraxlignolide D (15) showed excellent ACLY inhibitory effect with IC(50) values of 9.06, 0.59, 2.63, and 7.62 muM, respectively. These compounds were further evaluated for their cholesterol-lowing effects on ox-LDL-induced high-cholesterol HepG2 cells. Compound 15 emerges as the most potent ACLY inhibitor, which significantly decreased the TC level in a dose-dependent manner. In addition, molecular docking simulations elucidated that 15 formed a strong hydrogen-bond interaction with Glu599 of ACLY, which was an important site responsible for the enzyme catalytic activity.
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