Hypoglaucin ACAS# 93528-39-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 93528-39-3 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C45H72O16 | M.Wt | 869 |
| Type of Compound | Steroids | Storage | Desiccate at -20°C |
| Synonyms | Lieguonin B | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Hypoglaucin A Dilution Calculator
Hypoglaucin A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.1507 mL | 5.7537 mL | 11.5075 mL | 23.015 mL | 28.7687 mL |
| 5 mM | 0.2301 mL | 1.1507 mL | 2.3015 mL | 4.603 mL | 5.7537 mL |
| 10 mM | 0.1151 mL | 0.5754 mL | 1.1507 mL | 2.3015 mL | 2.8769 mL |
| 50 mM | 0.023 mL | 0.1151 mL | 0.2301 mL | 0.4603 mL | 0.5754 mL |
| 100 mM | 0.0115 mL | 0.0575 mL | 0.1151 mL | 0.2301 mL | 0.2877 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.[Pubmed:15789559]
Mol Divers. 2005;9(1-3):123-9.
The chemokines (CXCL9, CXCL10 and CXCL11) and associated CXCR3 receptor are expressed during the inflammatory process from multiple sclerosis, atherosclerosis or organ transplantation resulting in the recruitment of lymphocytes leading to tissue damage. It is hypothesized that blocking of the ligand/CXCR3 receptor interaction has potential to provide opportunity for development of agents that would block tissue rejection. In this paper, four classes of natural product inhibitors (IC50 ranging 0.1-41 microM) have been described that block the CXCR3 receptor interaction of IP-10 ligand. These include a cyclic thiopeptide (duramycin), polyketide glycosides (roselipins), steroidal glycosides (hypoglausin A and dioscin) and a novel alkyl pyridinium alkaloid that were isolated by bioassay-guided fractionation of the organic extracts derived from actinomycete, fungal, plant and marine sources and discovered using 125I IP-10/CXCR3 binding assay. Duramycin was the most potent with an IC50 of 0.1 microM. Roselipins 2A, 2B and 1A showed IC50 values of 14.6, 23.5, and 41 microM, respectively. Diosgenin glycosides dioscin, Hypoglaucin A and kallstroemin D exhibited IC50 values of 2.1, 0.47 and 3 microM, respectively. A novel cyclic 3-alkyl pyridinium salt isolated from a sponge displayed a binding IC50 of 0.67 microM.
