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Justicidin D

CAS# 27041-98-1

Justicidin D

Catalog No. BCX0154----Order now to get a substantial discount!

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Justicidin D: 5mg $460 In Stock
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Chemical structure

Justicidin D

3D structure

Chemical Properties of Justicidin D

Cas No. 27041-98-1 SDF Download SDF
PubChem ID 5318737 Appearance Powder
Formula C21H14O7 M.Wt 378.3
Type of Compound Lignans Storage Desiccate at -20°C
Synonyms Neojusticin A
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 9-(1,3-benzodioxol-5-yl)-5-methoxy-8H-[2]benzofuro[6,5-f][1,3]benzodioxol-6-one
SMILES COC1=C2C(=C(C3=CC4=C(C=C31)OCO4)C5=CC6=C(C=C5)OCO6)COC2=O
Standard InChIKey WOELDRZIQLRDQB-UHFFFAOYSA-N
Standard InChI InChI=1S/C21H14O7/c1-23-20-12-6-17-16(27-9-28-17)5-11(12)18(13-7-24-21(22)19(13)20)10-2-3-14-15(4-10)26-8-25-14/h2-6H,7-9H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Justicidin D

The herbs of Phyllanthus piscatorum

Justicidin D Dilution Calculator

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Preparing Stock Solutions of Justicidin D

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6434 mL 13.217 mL 26.434 mL 52.8681 mL 66.0851 mL
5 mM 0.5287 mL 2.6434 mL 5.2868 mL 10.5736 mL 13.217 mL
10 mM 0.2643 mL 1.3217 mL 2.6434 mL 5.2868 mL 6.6085 mL
50 mM 0.0529 mL 0.2643 mL 0.5287 mL 1.0574 mL 1.3217 mL
100 mM 0.0264 mL 0.1322 mL 0.2643 mL 0.5287 mL 0.6609 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Justicidin D

Reveals of candidate active ingredients in Justicia and its anti-thrombotic action of mechanism based on network pharmacology approach and experimental validation.[Pubmed:34433871]

Sci Rep. 2021 Aug 25;11(1):17187.

Thrombotic diseases seriously threaten human life. Justicia, as a common Chinese medicine, is usually used for anti-inflammatory treatment, and further studies have found that it has an inhibitory effect on platelet aggregation. Therefore, it can be inferred that Justicia can be used as a therapeutic drug for thrombosis. This work aims to reveal the pharmacological mechanism of the anti-thrombotic effect of Justicia through network pharmacology combined with wet experimental verification. During the analysis, 461 compound targets were predicted from various databases and 881 thrombus-related targets were collected. Then, herb-compound-target network and protein-protein interaction network of disease and prediction targets were constructed and cluster analysis was applied to further explore the connection between the targets. In addition, Gene Ontology (GO) and pathway (KEGG) enrichment were used to further determine the association between target proteins and diseases. Finally, the expression of hub target proteins of the core component and the anti-thrombotic effect of Justicia's core compounds were verified by experiments. In conclusion, the core bioactive components, especially Justicidin D, can reduce thrombosis by regulating F2, MMP9, CXCL12, MET, RAC1, PDE5A, and ABCB1. The combination of network pharmacology and the experimental research strategies proposed in this paper provides a comprehensive method for systematically exploring the therapeutic mechanism of multi-component medicine.

Structure-based virtual screening of bioactive compounds from Indonesian medical plants against severe acute respiratory syndrome coronavirus-2.[Pubmed:34159141]

J Adv Pharm Technol Res. 2021 Apr-Jun;12(2):120-126.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a virus that causes the infectious disease coronavirus disease-2019. Currently, there is no effective drug for the prevention and treatment of this virus. This study aimed to identify secondary metabolites that potentially inhibit the key proteins of SARS-CoV-2. This was an in silico molecular docking study of several secondary metabolites of Indonesian herbal plant compounds and other metabolites with antiviral testing history. Virtual screening using AutoDock Vina of 216 Lipinski rule-compliant plant metabolites was performed on 3C-like protease (3CL(pro)), RNA-dependent RNA polymerase (RdRp), and spike glycoprotein. Ligand preparation was performed using JChem and Schrodinger's software, and virtual protein elucidation was performed using AutoDockTools version 1.5.6. Virtual screening identified several RdRp, spike, and 3CL(pro) inhibitors. Justicidin D had binding affinities of -8.7, -8.1, and -7.6 kcal mol(-1) on RdRp, 3CL(pro), and spike, respectively. 10-methoxycamptothecin had binding affinities of -8.5 and -8.2 kcal mol(-1) on RdRp and spike, respectively. Inoxanthone had binding affinities of -8.3 and -8.1 kcal mol(-1) on RdRp and spike, respectively, while binding affinities of caribine were -9.0 and -7.5 mol(-1) on 3CL(pro) and spike, respectively. Secondary metabolites of compounds from several plants were identified as potential agents for SARS-CoV-2 therapy.

Coronavirus disease 2019 drug discovery through molecular docking.[Pubmed:32704354]

F1000Res. 2020 Jun 3;9:502.

Background: The dawn of the year 2020 witnessed the spread of the highly infectious and communicable disease coronavirus disease 2019 (COVID-19) globally since it was fi rst reported in 2019. Severe acute respiratory syndrome coronavirus-2 is the main causative agent. In total, 3,096,626 cases and 217,896 deaths owing to COVID-19 were reported by 30th April, 2020 by the World Health Organization. This means infection and deaths show an exponential growth globally. In order to tackle this pandemic, it is necessary to fi nd possible easily accessible therapeutic agents till an effective vaccine is developed. Methods: In this study, we present the results of molecular docking processes through high throughput virtual screening to analyze drugs recommended for the treatment of COVID-19. Results: Atovaquone, fexofenadine acetate (Allegra), ethamidindole, baicalin, glycyrrhetic acid, Justicidin D, euphol, and curine are few of the lead molecules found after docking 129 known antivirals, antimalarial, antiparasitic drugs and 992 natural products. Conclusions: These molecules could act as an effective inhibitory drug against COVID-19.

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