KoenigicineCAS# 24123-92-0 |
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| Cas No. | 24123-92-0 | SDF | Download SDF |
| PubChem ID | 278055 | Appearance | Yellow powder |
| Formula | C20H21NO3 | M.Wt | 323.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | Kenidine; Kenigicine; Kenimbidine; Koenidine; Koenimbidine | ||
| Solubility | Soluble in methanol; slightly soluble in water | ||
| Chemical Name | 8,9-dimethoxy-3,3,5-trimethyl-11H-pyrano[3,2-a]carbazole | ||
| SMILES | CC1=CC2=C(C3=C1OC(C=C3)(C)C)NC4=CC(=C(C=C42)OC)OC | ||
| Standard InChIKey | IUZVYLWUISSZCS-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H21NO3/c1-11-8-14-13-9-16(22-4)17(23-5)10-15(13)21-18(14)12-6-7-20(2,3)24-19(11)12/h6-10,21H,1-5H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Koenigicine Dilution Calculator
Koenigicine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0921 mL | 15.4607 mL | 30.9215 mL | 61.8429 mL | 77.3036 mL |
| 5 mM | 0.6184 mL | 3.0921 mL | 6.1843 mL | 12.3686 mL | 15.4607 mL |
| 10 mM | 0.3092 mL | 1.5461 mL | 3.0921 mL | 6.1843 mL | 7.7304 mL |
| 50 mM | 0.0618 mL | 0.3092 mL | 0.6184 mL | 1.2369 mL | 1.5461 mL |
| 100 mM | 0.0309 mL | 0.1546 mL | 0.3092 mL | 0.6184 mL | 0.773 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Versatile oxidative approach to carbazoles and related compounds using MoCl5.[Pubmed:24354638]
Org Lett. 2014 Jan 17;16(2):402-5.
The unique oxidizing power of molybdenum pentachloride provides an easy to perform, versatile, and high yielding method to construct carbazoles and the corresponding dibenzo analogues of thiophene, furan, and selenophene. The coupling reaction tolerates a variety of functional groups. The synthesis is highly modular. By this approach a precursor for the naturally occurring carbazole Koenigicine was prepared.
Pancreatic lipase inhibitory alkaloids of Murraya koenigii leaves.[Pubmed:19768989]
Nat Prod Commun. 2009 Aug;4(8):1089-92.
In the continuing search for newer pancreatic lipase inhibitors from plants, a total of 63 extracts from 21 different plants were screened to study their pancreatic lipase (PL) inhibitory activity in vitro. All three extracts (DCM, EtOAc and MeOH) of Murraya koenigii (L.) Spreng leaves (Rutaceae) exhibited antilipase activity greater than 80%. Further, bioactivity guided fractionation of the EtOAc extract led to the isolation of four alkaloids, namely mahanimbin, koenimbin, Koenigicine and clausazoline-K, with IC50 values of 17.9 microM, 168.6 microM, 428.6 microM and <500 microM, respectively. This study reports for the first time the PL inhibitory potential of carbazole alkaloids from plants.
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