Mangostanol

CAS# 184587-72-2

Mangostanol

2D Structure

Catalog No. BCN1151----Order now to get a substantial discount!

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Quality Control of Mangostanol

3D structure

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Mangostanol

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Chemical Properties of Mangostanol

Cas No. 184587-72-2 SDF Download SDF
PubChem ID 10048103 Appearance Yellow powder
Formula C24H26O7 M.Wt 426.5
Type of Compound Xanthones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3,5,9-trihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-3,4-dihydropyrano[3,2-b]xanthen-6-one
SMILES CC(=CCC1=C2C(=CC(=C1OC)O)OC3=CC4=C(CC(C(O4)(C)C)O)C(=C3C2=O)O)C
Standard InChIKey KCMPFWGUVNEDHW-UHFFFAOYSA-N
Standard InChI InChI=1S/C24H26O7/c1-11(2)6-7-12-19-16(9-14(25)23(12)29-5)30-17-10-15-13(21(27)20(17)22(19)28)8-18(26)24(3,4)31-15/h6,9-10,18,25-27H,7-8H2,1-5H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Mangostanol

The fruits of Garcinia mangostana

Biological Activity of Mangostanol

Description1. Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell line, with IC50 values of 9.6 microg/ml. 2. Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.

Mangostanol Dilution Calculator

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Mangostanol Molarity Calculator

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Preparing Stock Solutions of Mangostanol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3447 mL 11.7233 mL 23.4467 mL 46.8933 mL 58.6166 mL
5 mM 0.4689 mL 2.3447 mL 4.6893 mL 9.3787 mL 11.7233 mL
10 mM 0.2345 mL 1.1723 mL 2.3447 mL 4.6893 mL 5.8617 mL
50 mM 0.0469 mL 0.2345 mL 0.4689 mL 0.9379 mL 1.1723 mL
100 mM 0.0234 mL 0.1172 mL 0.2345 mL 0.4689 mL 0.5862 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Mangostanol

Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies.[Pubmed:25172794]

Phytomedicine. 2014 Sep 25;21(11):1303-9.

Garcinia mangostana is a well-known tropical plant found mostly in South East Asia. The present study investigated acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of G. mangostana extract and its chemical constituents using Ellman's colorimetric method. Cholinesterase inhibitory-guided approach led to identification of six bioactive prenylated xanthones showing moderate to potent cholinesterases inhibition with IC50 values of lower than 20.5 muM. The most potent inhibitor of AChE was garcinone C while gamma-mangostin was the most potent inhibitor of BChE with IC50 values of 1.24 and 1.78 muM, respectively. Among the xanthones, Mangostanol, 3-isomangostin, garcinone C and alpha-mangostin are AChE selective inhibitors, 8-deoxygartanin is a BChE selective inhibitor while gamma-mangostin is a dual inhibitor. Preliminary structure-activity relationship suggests the importance of the C-8 prenyl and C-7 hydroxy groups for good AChE and BChE inhibitory activities. The enzyme kinetic studies indicate that both alpha-mangostin and garcinone C are mixed-mode inhibitors, while gamma-mangostin is a non-competitive inhibitor of AChE. In contrast, both gamma-mangostin and garcinone C are uncompetitive inhibitors, while alpha-mangostin is a mixed-mode inhibitor of BChE. Molecular docking studies revealed that alpha-mangostin, gamma-mangostin and garcinone C interacts differently with the five important regions of AChE and BChE. The nature of protein-ligand interactions is mainly hydrophobic and hydrogen bonding. These bioactive prenylated xanthones are worthy for further investigations.

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