MarginatoxinCAS# 1422536-56-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
Cas No. | 1422536-56-8 | SDF | Download SDF |
PubChem ID | N/A | Appearance | Powder |
Formula | C22H22O7 | M.Wt | 398.4 |
Type of Compound | Lignans | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway. |
Targets | Caspase | Fas/FasL |
In vitro | A novel cytotoxic aryltetraline lactone from Bupleurum marginatum (Apiaceae)[Reference: WebLink]Phytochemistry Letters, 2012, 5(2):387-392.
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Kinase Assay | Marginatoxin induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.[Reference: WebLink]Biomedical Research,2017,28(3).
Marginatoxin, an aryltetraline lactone lignan isolated from Bupleurum marginatum Wall. ex DC (Apiaceae), showed cytotoxic activity against human hepatocellular carcinoma. However, the cytotoxic mechanisms of Marginatoxin against cancer cells remained unclear. |
Marginatoxin Dilution Calculator
Marginatoxin Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.51 mL | 12.5502 mL | 25.1004 mL | 50.2008 mL | 62.751 mL |
5 mM | 0.502 mL | 2.51 mL | 5.0201 mL | 10.0402 mL | 12.5502 mL |
10 mM | 0.251 mL | 1.255 mL | 2.51 mL | 5.0201 mL | 6.2751 mL |
50 mM | 0.0502 mL | 0.251 mL | 0.502 mL | 1.004 mL | 1.255 mL |
100 mM | 0.0251 mL | 0.1255 mL | 0.251 mL | 0.502 mL | 0.6275 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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