NPS ALX Compound 4a dihydrochloridePotent and selective 5-HT6 antagonist CAS# 299433-10-6 |
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| Cas No. | 299433-10-6 | SDF | Download SDF |
| PubChem ID | 124081031 | Appearance | Powder |
| Formula | C25H27Cl2N3O2S | M.Wt | 504.47 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO | ||
| Chemical Name | (8aS)-2-(1-naphthalen-1-ylsulfonylindol-6-yl)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazine;dihydrochloride | ||
| SMILES | C1CC2CN(CCN2C1)C3=CC4=C(C=C3)C=CN4S(=O)(=O)C5=CC=CC6=CC=CC=C65.Cl.Cl | ||
| Standard InChIKey | XQQYORJJFZQWNA-IKXQUJFKSA-N | ||
| Standard InChI | InChI=1S/C25H25N3O2S.2ClH/c29-31(30,25-9-3-6-19-5-1-2-8-23(19)25)28-14-12-20-10-11-21(17-24(20)28)27-16-15-26-13-4-7-22(26)18-27;;/h1-3,5-6,8-12,14,17,22H,4,7,13,15-16,18H2;2*1H/t22-;;/m0../s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent and competitive 5-HT6 antagonist (IC50 = 7.2 nM, Ki = 0.2 nM) that displays selectivity over other 5-HT and D2 receptors. |
NPS ALX Compound 4a dihydrochloride Dilution Calculator
NPS ALX Compound 4a dihydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9823 mL | 9.9114 mL | 19.8228 mL | 39.6456 mL | 49.557 mL |
| 5 mM | 0.3965 mL | 1.9823 mL | 3.9646 mL | 7.9291 mL | 9.9114 mL |
| 10 mM | 0.1982 mL | 0.9911 mL | 1.9823 mL | 3.9646 mL | 4.9557 mL |
| 50 mM | 0.0396 mL | 0.1982 mL | 0.3965 mL | 0.7929 mL | 0.9911 mL |
| 100 mM | 0.0198 mL | 0.0991 mL | 0.1982 mL | 0.3965 mL | 0.4956 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist with an IC50 of 7.2 nM, which also has a great binding affinity with Ki of 0.2 nM.
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