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Norfluorocurarine

CAS# 6880-54-2

Norfluorocurarine

Catalog No. BCN4811----Order now to get a substantial discount!

Product Name & Size Price Stock
Norfluorocurarine: 5mg $828 In Stock
Norfluorocurarine: 10mg Please Inquire In Stock
Norfluorocurarine: 20mg Please Inquire Please Inquire
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Quality Control of Norfluorocurarine

Number of papers citing our products

Chemical structure

Norfluorocurarine

3D structure

Chemical Properties of Norfluorocurarine

Cas No. 6880-54-2 SDF Download SDF
PubChem ID 5581319 Appearance Powder
Formula C19H20N2O M.Wt 292.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC=C1CN2CCC34C2CC1C(=C3NC5=CC=CC=C45)C=O
Standard InChIKey VFUITWPFKLGEQA-UQZDHWHBSA-N
Standard InChI InChI=1S/C19H20N2O/c1-2-12-10-21-8-7-19-15-5-3-4-6-16(15)20-18(19)14(11-22)13(12)9-17(19)21/h2-6,11,13,17,20H,7-10H2,1H3/b12-2-/t13-,17-,19+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Norfluorocurarine

The herbs of Alstonia yunnanensis

Biological Activity of Norfluorocurarine

DescriptionStandard reference
In vitro

The Intramolecular Diels-Alder Reaction of Tryptamine-Derived Zincke Aldehydes Is a Stepwise Process.[Pubmed: 22611483]

Chem Sci. 2012;2012(3):1650-1655.


METHODS AND RESULTS:
Computational studies show that the base-mediated intramolecular Diels-Alder of tryptamine-derived Zincke aldehydes, used as a key step in the synthesis of the Strychnos alkaloids Norfluorocurarine and strychnine, proceeds via a stepwise pathway. The experimentally determined importance of a potassium counterion in the base is explained by its ability to preorganize the Zincke aldehyde diene in an s-cis conformation suitable to bicyclization. Computation also supports the thermodynamic importance of the generation of a stable enolate in the final reaction step.
CONCLUSIONS:
The thermal cycloreversion reaction of the Diels-Alder products is also found to proceed in a stepwise manner.

Protocol of Norfluorocurarine

Structure Identification
J Am Chem Soc. 2009 Mar 18;131(10):3472-3.

Efficient access to the core of the Strychnos, Aspidosperma and Iboga alkaloids. A short synthesis of norfluorocurarine.[Pubmed: 19236094]


METHODS AND RESULTS:
An efficient anionic bicyclization of tryptamine-derived Zincke aldehydes forms the basis for a three-step route to the tetracyclic ABCE core of many Strychnos, Aspidosperma, and Iboga alkaloids. This powerful reaction is showcased in a five-step synthesis of the Strychnos alkaloid Norfluorocurarine from tryptamine and pyridine.

Norfluorocurarine Dilution Calculator

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Norfluorocurarine Molarity Calculator

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Preparing Stock Solutions of Norfluorocurarine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.42 mL 17.0999 mL 34.1997 mL 68.3995 mL 85.4993 mL
5 mM 0.684 mL 3.42 mL 6.8399 mL 13.6799 mL 17.0999 mL
10 mM 0.342 mL 1.71 mL 3.42 mL 6.8399 mL 8.5499 mL
50 mM 0.0684 mL 0.342 mL 0.684 mL 1.368 mL 1.71 mL
100 mM 0.0342 mL 0.171 mL 0.342 mL 0.684 mL 0.855 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Norfluorocurarine

The Intramolecular Diels-Alder Reaction of Tryptamine-Derived Zincke Aldehydes Is a Stepwise Process.[Pubmed:22611483]

Chem Sci. 2012;2012(3):1650-1655.

Computational studies show that the base-mediated intramolecular Diels-Alder of tryptamine-derived Zincke aldehydes, used as a key step in the synthesis of the Strychnos alkaloids Norfluorocurarine and strychnine, proceeds via a stepwise pathway. The experimentally determined importance of a potassium counterion in the base is explained by its ability to preorganize the Zincke aldehyde diene in an s-cis conformation suitable to bicyclization. Computation also supports the thermodynamic importance of the generation of a stable enolate in the final reaction step. The thermal cycloreversion reaction of the Diels-Alder products is also found to proceed in a stepwise manner.

Efficient access to the core of the Strychnos, Aspidosperma and Iboga alkaloids. A short synthesis of norfluorocurarine.[Pubmed:19236094]

J Am Chem Soc. 2009 Mar 18;131(10):3472-3.

An efficient anionic bicyclization of tryptamine-derived Zincke aldehydes forms the basis for a three-step route to the tetracyclic ABCE core of many Strychnos, Aspidosperma, and Iboga alkaloids. This powerful reaction is showcased in a five-step synthesis of the Strychnos alkaloid Norfluorocurarine from tryptamine and pyridine.

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