Piperlotine CCAS# 886989-88-4 |
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| Cas No. | 886989-88-4 | SDF | Download SDF |
| PubChem ID | 808227 | Appearance | Powder |
| Formula | C16H21NO4 | M.Wt | 291.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E)-1-pyrrolidin-1-yl-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one | ||
| SMILES | COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCCC2 | ||
| Standard InChIKey | TYFKYDTUEMTUNY-VOTSOKGWSA-N | ||
| Standard InChI | InChI=1S/C16H21NO4/c1-19-13-10-12(11-14(20-2)16(13)21-3)6-7-15(18)17-8-4-5-9-17/h6-7,10-11H,4-5,8-9H2,1-3H3/b7-6+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Piper nigrum L.
| Description | 1. Piperlotine C shows potent antiplatelet aggregation activity. |
| Targets | PAFR |
Piperlotine C Dilution Calculator
Piperlotine C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.4317 mL | 17.1585 mL | 34.3171 mL | 68.6342 mL | 85.7927 mL |
| 5 mM | 0.6863 mL | 3.4317 mL | 6.8634 mL | 13.7268 mL | 17.1585 mL |
| 10 mM | 0.3432 mL | 1.7159 mL | 3.4317 mL | 6.8634 mL | 8.5793 mL |
| 50 mM | 0.0686 mL | 0.3432 mL | 0.6863 mL | 1.3727 mL | 1.7159 mL |
| 100 mM | 0.0343 mL | 0.1716 mL | 0.3432 mL | 0.6863 mL | 0.8579 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation and identification of antiplatelet aggregatory principles from the leaves of Piper lolot.[Pubmed:17941696]
J Agric Food Chem. 2007 Nov 14;55(23):9436-42.
The methanolic extract of Piper lolot, having shown potent inhibitory activity on platelet aggregation induced by arachidonic acid (AA) and platelet activating factor (PAF), was subjected to activity-guided isolation to yield twelve new amide alkaloids, piperlotine A-L (1-12), along with twenty-nine known compounds. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were tested for their inhibitory activity on the rabbit platelet aggregation. The compounds piperlotine A (1), Piperlotine C (3), piperlotine D (4), piperlotine E (5), 3-phenyl-1-(2,4,6-trihydroxyphenyl)propan-1-one (21), 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (22), 1-trans-cinnamoylpyrrolidine (24), sarmentine (26), pellitorine (27), methyl 3-phenylpropionate (32), and (10S)-10-hydroxypheophorbide a methyl ester (40) showed potent antiplatelet aggregation activity.
Piperlotine C is an alkaloid isolated from Piper lolot, with anti-platelet aggregation induced by arachidonic acid, and the IC50 is 26.6 µg/mL.
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