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Pseudolaric acid A

CAS# 82508-32-5

Pseudolaric acid A

2D Structure

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Pseudolaric acid A: 5mg $35 In Stock
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Quality Control of Pseudolaric acid A

3D structure

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Pseudolaric acid A

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Chemical Properties of Pseudolaric acid A

Cas No. 82508-32-5 SDF Download SDF
PubChem ID 6436278 Appearance White powder
Formula C22H28O6 M.Wt 388.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in chloroform, DMSO and ethan
SMILES CC1=CCC23CCC(C2(CC1)OC(=O)C)C(OC3=O)(C)C=CC=C(C)C(=O)O
Standard InChIKey GOHMRMDXUXWCDQ-MPVZDDSSSA-N
Standard InChI InChI=1S/C22H28O6/c1-14-7-11-21-12-9-17(22(21,13-8-14)27-16(3)23)20(4,28-19(21)26)10-5-6-15(2)18(24)25/h5-7,10,17H,8-9,11-13H2,1-4H3,(H,24,25)/b10-5+,15-6+/t17-,20+,21+,22-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Pseudolaric acid A

The root bark of Pseudolarix amabilis

Biological Activity of Pseudolaric acid A

DescriptionPseudolaric acid A and -B can inhibit the growth of particular cell type.
In vitro

The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives.[Pubmed: 2236294]

Planta Med. 1990 Aug;56(4):383-5.


METHODS AND RESULTS:
Pseudolaric acid A and Pseudolaric acid B, the novel diterpene acids isolated from Pseudolarix kaempferi, and their related derivatives have been tested for cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells. The results showed that Pseudolaric acid A and Pseudolaric acid B demonstrated potent cytotoxicity.
CONCLUSIONS:
The selectivity of Pseudolaric acid A and Pseudolaric acid B which inhibit the growth of particular cell types within the disease-oriented human cancer cell line panels is discussed.

Pseudolaric acid A Dilution Calculator

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Pseudolaric acid A Molarity Calculator

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Preparing Stock Solutions of Pseudolaric acid A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.574 mL 12.87 mL 25.74 mL 51.4801 mL 64.3501 mL
5 mM 0.5148 mL 2.574 mL 5.148 mL 10.296 mL 12.87 mL
10 mM 0.2574 mL 1.287 mL 2.574 mL 5.148 mL 6.435 mL
50 mM 0.0515 mL 0.2574 mL 0.5148 mL 1.0296 mL 1.287 mL
100 mM 0.0257 mL 0.1287 mL 0.2574 mL 0.5148 mL 0.6435 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Pseudolaric acid A

The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives.[Pubmed:2236294]

Planta Med. 1990 Aug;56(4):383-5.

Pseudolaric acid-A and -B, the novel diterpene acids isolated from Pseudolarix kaempferi, and their related derivatives have been tested for cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells. The results showed that pseudolaric acid-A and -B demonstrated potent cytotoxicity. The selectivity of pseudolaric acid-A and -B which inhibit the growth of particular cell types within the disease-oriented human cancer cell line panels is discussed.

Description

Pseudolaric Acid A is a diterpene acid isolated from Pseudolarix kaempferi, has antifungal, cytotoxic and antifertile activities.

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