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Psoracorylifol A

CAS# 879290-97-8

Psoracorylifol A

2D Structure

Catalog No. BCN3611----Order now to get a substantial discount!

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Quality Control of Psoracorylifol A

3D structure

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Psoracorylifol A

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Chemical Properties of Psoracorylifol A

Cas No. 879290-97-8 SDF Download SDF
PubChem ID 11848147 Appearance Powder
Formula C18H24O3 M.Wt 288.4
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-[(S)-[(3S,6S)-3-ethenyl-3-methyl-6-prop-1-en-2-yloxan-2-yl]-hydroxymethyl]phenol
SMILES CC(=C)C1CCC(C(O1)C(C2=CC=C(C=C2)O)O)(C)C=C
Standard InChIKey VLFQGDGCZKMBDA-UKSPMXFCSA-N
Standard InChI InChI=1S/C18H24O3/c1-5-18(4)11-10-15(12(2)3)21-17(18)16(20)13-6-8-14(19)9-7-13/h5-9,15-17,19-20H,1-2,10-11H2,3-4H3/t15-,16-,17?,18+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Psoracorylifol A

The herbs of Psoralea corylifolia Linn.

Protocol of Psoracorylifol A

Structure Identification
Tetrahedron, 2006, 62(11):2569-2575.

Psoracorylifols A–E, five novel compounds with activity against Helicobacter pylori from seeds of Psoralea corylifolia.[Reference: WebLink]


METHODS AND RESULTS:
Five novel compounds, Psoracorylifol A, psoracorylifol B, psoracorylifol C, psoracorylifol D, psoracorylifol E (1–5) with important activity against Helicobacter pylori have been isolated from a well-known traditional Chinese medicine (TCM), the seeds of Psoralea corylifolia. The structures of compounds 1–5, including their absolute configurations, were established on the basis of spectral methods and biogenetic reason. The structure of 1 was confirmed by a single-crystal X-ray diffraction.
CONCLUSIONS:
Psoracorylifols D and E (4 and 5) represent an unprecedented carbon skeleton. The biogenetic origin of psoracorylifols A–E (1–5) was also postulated.

Psoracorylifol A Dilution Calculator

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Psoracorylifol A Molarity Calculator

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Preparing Stock Solutions of Psoracorylifol A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4674 mL 17.337 mL 34.6741 mL 69.3481 mL 86.6852 mL
5 mM 0.6935 mL 3.4674 mL 6.9348 mL 13.8696 mL 17.337 mL
10 mM 0.3467 mL 1.7337 mL 3.4674 mL 6.9348 mL 8.6685 mL
50 mM 0.0693 mL 0.3467 mL 0.6935 mL 1.387 mL 1.7337 mL
100 mM 0.0347 mL 0.1734 mL 0.3467 mL 0.6935 mL 0.8669 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Psoracorylifol A

Scalable asymmetric total syntheses of (+)-Psoracorylifol B and (+)-ent-Psoracorylifol C.[Pubmed:24819702]

Org Lett. 2014 Jun 6;16(11):2986-9.

The first, asymmetric total syntheses of potent antimicrobial Psoracorylifol B (>1.3 g obtained, dr 10.5:1) with a 9.4% overall yield on a gram scale in 14 steps and ent-Psoracorylifol C with a 4.3% yield in 16 steps were achieved. The key features of our synthesis include (i) sequential, rarely explored Achmatowicz rearrangement/bicycloketalization to construct the 6,8-dioxabicyclo[3.2.1]octane core, and (ii) Cu-mediated SN2' methylation or Johnson-Claisen rearrangement to stereoselectively install the all-carbon quaternary stereocenter. This concise, highly efficient, and scalable synthetic route may provide expedited and practical access to psoracorylifols and their analogues for further biological activity evaluation.

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