Home >> Research Area >>GPCR/G protein>>5-HT Receptor>> CP 93129 dihydrochloride

CP 93129 dihydrochloride

5-HT1B agonist CAS# 879089-64-2

CP 93129 dihydrochloride

Catalog No. BCC6899----Order now to get a substantial discount!

Product Name & Size Price Stock
CP 93129 dihydrochloride: 5mg $92 In Stock
CP 93129 dihydrochloride: 10mg Please Inquire In Stock
CP 93129 dihydrochloride: 20mg Please Inquire Please Inquire
CP 93129 dihydrochloride: 50mg Please Inquire Please Inquire
CP 93129 dihydrochloride: 100mg Please Inquire Please Inquire
CP 93129 dihydrochloride: 200mg Please Inquire Please Inquire
CP 93129 dihydrochloride: 500mg Please Inquire Please Inquire
CP 93129 dihydrochloride: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of CP 93129 dihydrochloride

Number of papers citing our products

Chemical structure

CP 93129 dihydrochloride

3D structure

Chemical Properties of CP 93129 dihydrochloride

Cas No. 879089-64-2 SDF Download SDF
PubChem ID 46927988 Appearance Powder
Formula C12H15Cl2N3O M.Wt 288.18
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in water
Chemical Name 3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydropyrrolo[3,2-b]pyridin-5-one;dihydrochloride
SMILES C1CNCC=C1C2=CNC3=C2NC(=O)C=C3.Cl.Cl
Standard InChIKey FLVJHUZZKVJQNH-UHFFFAOYSA-N
Standard InChI InChI=1S/C12H13N3O.2ClH/c16-11-2-1-10-12(15-11)9(7-14-10)8-3-5-13-6-4-8;;/h1-3,7,13-14H,4-6H2,(H,15,16);2*1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of CP 93129 dihydrochloride

DescriptionPotent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.

CP 93129 dihydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

CP 93129 dihydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of CP 93129 dihydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4701 mL 17.3503 mL 34.7005 mL 69.4011 mL 86.7513 mL
5 mM 0.694 mL 3.4701 mL 6.9401 mL 13.8802 mL 17.3503 mL
10 mM 0.347 mL 1.735 mL 3.4701 mL 6.9401 mL 8.6751 mL
50 mM 0.0694 mL 0.347 mL 0.694 mL 1.388 mL 1.735 mL
100 mM 0.0347 mL 0.1735 mL 0.347 mL 0.694 mL 0.8675 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on CP 93129 dihydrochloride

Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex.[Pubmed:24381287]

J Neurosci. 2014 Jan 1;34(1):260-74.

G(i/o)-protein-coupled receptors (GPCRs) ubiquitously inhibit neurotransmission, principally via Gbetagamma, which acts via a number of possible effectors. GPCR effector specificity has traditionally been attributed to Galpha, based on Galpha's preferential effector targeting in vitro compared with Gbetagamma's promiscuous targeting of various effectors. In synapses, however, Gbetagamma clearly targets unique effectors in a receptor-dependent way to modulate synaptic transmission. It remains unknown whether Gbetagamma specificity in vivo is due to specific Gbetagamma isoform-receptor associations or to spatial separation of distinct Gbetagamma pathways through macromolecular interactions. We thus sought to determine how Gbetagamma signaling pathways within axons remain distinct from one another. In rat hippocampal CA1 axons, GABA(B) receptors (GABA(B)Rs) inhibit presynaptic Ca(2+) entry, and we have now demonstrated that 5-HT(1B) receptors (5-HT(1B)Rs) liberate Gbetagamma to interact with SNARE complex C terminals with no effect on Ca(2+) entry. Both GABA(B)Rs and 5-HT(1B)Rs inhibit Ca(2+)-evoked neurotransmitter release, but 5-HT(1B)Rs have no effect on Sr(2+)-evoked release. Sr(2+), unlike Ca(2+), does not cause synaptotagmin to compete with Gbetagamma binding to SNARE complexes. 5-HT(1B)Rs also fail to inhibit release following cleavage of the C terminus of the SNARE complex protein SNAP-25 with botulinum A toxin. Thus, GABA(B)Rs and 5-HT(1B)Rs both localize to presynaptic terminals, but target distinct effectors. We demonstrate that disruption of SNARE complexes and vesicle priming with botulinum C toxin eliminates this selectivity, allowing 5-HT(1B)R inhibition of Ca(2+) entry. We conclude that receptor-effector specificity requires a microarchitecture provided by the SNARE complex during vesicle priming.

Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats.[Pubmed:9566817]

Psychopharmacology (Berl). 1998 Apr;136(3):304-7.

Unilateral infusion of the selective 5-HT1B agonist, CP-93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl) pyrrolo[3,2-b]pyrid-5-one) into the parabrachial nucleus (PBN) of the pons reduced food consumption by rats. The hypophagia was dose-related (ED50 approximately 1 nmol) and associated with fewer observations of feeding and more periods of inactivity. Water intake, grooming and exploratory activity were unaffected. CP-93,129 also decreased food intake when injected into the hypothalamic paraventricular nucleus, but this action was 50-fold less potent than administration into the PBN. Autoradiography demonstrated 5-HT1B sites in the PBN; this binding was displaced by CP-93,129. The results implicate parabrachial 5-HT1B receptors in mediating serotonergic enhancement of satiation.

Keywords:

CP 93129 dihydrochloride,879089-64-2,Natural Products,5-HT Receptor, buy CP 93129 dihydrochloride , CP 93129 dihydrochloride supplier , purchase CP 93129 dihydrochloride , CP 93129 dihydrochloride cost , CP 93129 dihydrochloride manufacturer , order CP 93129 dihydrochloride , high purity CP 93129 dihydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: