Randaiol

CAS# 87562-14-9

Randaiol

Catalog No. BCN4002----Order now to get a substantial discount!

Product Name & Size Price Stock
Randaiol: 5mg $615 In Stock
Randaiol: 10mg Please Inquire In Stock
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Quality Control of Randaiol

Number of papers citing our products

Chemical structure

Randaiol

3D structure

Chemical Properties of Randaiol

Cas No. 87562-14-9 SDF Download SDF
PubChem ID 13337243 Appearance Oil
Formula C15H14O3 M.Wt 242.3
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-(2-hydroxy-5-prop-2-enylphenyl)benzene-1,4-diol
SMILES C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)O)O
Standard InChIKey KIQCVMGDSBIIGW-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H14O3/c1-2-3-10-4-6-14(17)12(8-10)13-9-11(16)5-7-15(13)18/h2,4-9,16-18H,1,3H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Randaiol

The barks of Magnolia hypoleuca

Biological Activity of Randaiol

DescriptionRandaiol is a natural product from Magnolia hypoleuca.
In vitro

New biphenyl derivatives and anti-inflammatory constituents from the stem bark of Magnolia officinalis[Reference: WebLink]

Planta Medica, 2011 , 77 (12):42.

The stem bark of Magnolia officinalis Rehd. et Wils. (Magnoliaceae) has been used as a traditional medicine for the treatment of gastrointestinal disorders, bronchitis, and emphysema, in China, Taiwan, Japan, and Korea [1]. Chemical studies have revealed a variety of neo-lignans and alkaloids as constituents of this plant. Many of these compounds exhibit central depressant effect, muscle relaxation, and antigastric ulcer, antibacterial, antiallergic, vasorelaxant, and neurotrophic activities.
METHODS AND RESULTS:
Investigation on EtOAc-soluble fraction of the stem bark of M. officinalis has led to the isolation of three new biphenyls, 5-allyl-5'-(1-hydroxyallyloxy)biphenyl-2,2-diol (1), 5,5'-diallyl-2'-(allyloxy)biphenyl-2-ol (2), and 5,5'-diallyl-2'-(3-methylbut-2-enyloxy)biphenyl-2-ol (3), together with 12 known compounds, including four neolignans, magnolol (4), honokiol (5), (-)-monoterpenylmagnolol (6), and randainal (7), two norlignans, magnaldehyde D (8) and Randaiol (9), and six steroids, β-sitostenone (10), stigmasta-4,22-dien-3-one (11), β-sitosterol (12), stigmasterol (13), 3β-hydroxystigmast-5-en-7-one (14), and 3β-hydroxystigmasta-5,22-dien-7-one (15). The structure of new compounds (1-3) were determined through spectroscopic and MS analyses. Among the isolates, magnolol (4) and honokiol (5) exhibited potent inhibition against fMLP-induced superoxide production with IC50 values of 4.42±0.24 and 0.68±0.20μg/mL, respectively. In addition, magnolol (4) inhibited fMLP/CB-induced elastase release with an IC50 values of 1.45±0.20μg/mL.

Protocol of Randaiol

Structure Identification
Phytochemistry.1983;22(2):616–617.

Biphenyls from the heartwood of taiwan sassafras.[Reference: WebLink]

Two new biphenyls, randainal and Randaiol, have been isolated from the heartwood of Taiwan sassafras in addition to the known biphenyl magnolol which was found previously in the bark of Magnolia species.
METHODS AND RESULTS:
The two biphenyls were shown to be 2,2′-dihydroxy-5-allylbiphenyl-5′-propenal and 2,2′,5′-trihydroxy-5-allylbiphenyl on the basis of chemical and spectroscopic evidence.

Chinese Traditional & Herbal Drugs, 2013 , 44 (3) :260-264.

Chemical constituents in fractions with vasoactive activity from leaves of Magnolia officinalis[Reference: WebLink]

To study the chemical constituents in the fractions with vasoactive activity from the dried leaves of Magnolia officinalis.
METHODS AND RESULTS:
The compounds were isolated from the chloroform and n-butanol fractions by various chromatographic techniques and identified by spectroscopic methods.Sixteen compounds were obtained and identified as magnolol (1), magnaldehyde B (2), Randaiol (3), syringaresinol (4), 4, 4', 5-trihydroxy-1, 1'-di-2-propenylbiphenyl (5), lariciresinol (6), (7S, 8R) syringoylglycerol (7), coniferin (8), benzylic-β-D-allopyranoside (9), afzelin (10), isorhamnetin-3-O-β-D-glucoside (11), choerospondin (12), 5, 7-dihydroxy chromone-7-O-β-D-glucoside (13), erigeside C (14), tachioside (15), and uridine (16).
CONCLUSIONS:
Compounds 5-8 are isolated from this plant for the first time, and compounds 9-16 are isolated from this genus for the first time.

Randaiol Dilution Calculator

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Randaiol Molarity Calculator

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Preparing Stock Solutions of Randaiol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1271 mL 20.6356 mL 41.2712 mL 82.5423 mL 103.1779 mL
5 mM 0.8254 mL 4.1271 mL 8.2542 mL 16.5085 mL 20.6356 mL
10 mM 0.4127 mL 2.0636 mL 4.1271 mL 8.2542 mL 10.3178 mL
50 mM 0.0825 mL 0.4127 mL 0.8254 mL 1.6508 mL 2.0636 mL
100 mM 0.0413 mL 0.2064 mL 0.4127 mL 0.8254 mL 1.0318 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Randaiol

Phenolic constituents from the stem bark of Magnolia officinalis.[Pubmed:19086868]

J Nat Prod. 2009 Jan;72(1):168-71.

Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), Randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol, syringaldehyde, syringaresinol, and acteoside, were isolated from the MeOH-soluble part of a water extract of the stem bark of Magnolia officinalis. Among these compounds, 2-8b were studied for anti-inflammatory and antioxidative activities. Compound 7 displayed more potent antioxidative potential than 9. Compounds 4-7 effectively inhibited LPS-induced NO production, whereas 5 and 6 were more potent than 9.

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