Rubioncolin CCAS# 132242-52-5 |
Quality Control & MSDS
3D structure
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| Cas No. | 132242-52-5 | SDF | Download SDF |
| PubChem ID | 14777447 | Appearance | Powder |
| Formula | C27H22O6 | M.Wt | 442.46 |
| Type of Compound | Quinones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | methyl 4-(1,4-dioxonaphthalen-2-yl)oxy-1-hydroxy-3-(3-methylbut-2-enyl)naphthalene-2-carboxylate | ||
| SMILES | CC(=CCC1=C(C2=CC=CC=C2C(=C1C(=O)OC)O)OC3=CC(=O)C4=CC=CC=C4C3=O)C | ||
| Standard InChIKey | UERDSCMBQADHGN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C27H22O6/c1-15(2)12-13-20-23(27(31)32-3)25(30)18-10-6-7-11-19(18)26(20)33-22-14-21(28)16-8-4-5-9-17(16)24(22)29/h4-12,14,30H,13H2,1-3H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots and rhizomes of Rubia podantha.
| Description | 1. Rubioncolin C shows good cytotoxicity with IC50 value of 1.53 uM and NF-κB inhibitory activity with IC50 value of 2.97 uM. |
| Targets | NF-kB |
Rubioncolin C Dilution Calculator
Rubioncolin C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2601 mL | 11.3005 mL | 22.6009 mL | 45.2018 mL | 56.5023 mL |
| 5 mM | 0.452 mL | 2.2601 mL | 4.5202 mL | 9.0404 mL | 11.3005 mL |
| 10 mM | 0.226 mL | 1.13 mL | 2.2601 mL | 4.5202 mL | 5.6502 mL |
| 50 mM | 0.0452 mL | 0.226 mL | 0.452 mL | 0.904 mL | 1.13 mL |
| 100 mM | 0.0226 mL | 0.113 mL | 0.226 mL | 0.452 mL | 0.565 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Rubipodanones A-D, naphthohydroquinone dimers from the roots and rhizomes of Rubia podantha.[Pubmed:29132078]
Phytochemistry. 2018 Jan;145:153-160.
Four previously undescribed naphthohydroquinone dimers named rubipodanones A-D, together with 19 known quinones containing three known napthohydroquinone dimers named Rubioncolin C, methyl 5-hydroxy-dinaphtho[1,2-2',3']furan-7,12-dione-6-carboxylate and rubialatin B, were isolated from the roots and rhizomes of Rubia podantha. Their structures and absolute configurations were determined mainly by NMR, X-ray diffraction, and computational methods. Rubipodanones C and D, the glycosides of rubipodanone A and a pair of C-3 epimer, are the first identified dimeric napthohydroquinone glycosides from the Rubia plants. All naphthohydroquinone dimers were evaluated for their cytotoxicities against ten tumor cell lines and effects on the tumor-associated NF-kappaB signaling pathway, and Rubioncolin C showed the best cytotoxicity with IC50 value of 1.53 muM and NF-kappaB inhibitory activity with IC50 value of 2.97 muM. These results also demonstrated that the key roles of C-3 configuration and sugar group for biological activities of rubipodanone C.
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