VelutinamCAS# 146428-62-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 146428-62-8 | SDF | Download SDF |
| PubChem ID | 9994639 | Appearance | Yellow powder |
| Formula | C17H13NO4 | M.Wt | 295.3 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 6-hydroxy-14,15-dimethoxy-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1,3,5,7,9(16),12,14-heptaen-11-one | ||
| SMILES | COC1=C(C2=C3C=CC=C(C3=CC4=C2C(=C1)C(=O)N4)O)OC | ||
| Standard InChIKey | KUZNZVMKXPBYIB-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H13NO4/c1-21-13-7-10-14-11(18-17(10)20)6-9-8(4-3-5-12(9)19)15(14)16(13)22-2/h3-7,19H,1-2H3,(H,18,20) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Velutinam Dilution Calculator
Velutinam Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3864 mL | 16.9319 mL | 33.8639 mL | 67.7277 mL | 84.6597 mL |
| 5 mM | 0.6773 mL | 3.3864 mL | 6.7728 mL | 13.5455 mL | 16.9319 mL |
| 10 mM | 0.3386 mL | 1.6932 mL | 3.3864 mL | 6.7728 mL | 8.466 mL |
| 50 mM | 0.0677 mL | 0.3386 mL | 0.6773 mL | 1.3546 mL | 1.6932 mL |
| 100 mM | 0.0339 mL | 0.1693 mL | 0.3386 mL | 0.6773 mL | 0.8466 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Natural aristolactams and aporphine alkaloids as inhibitors of CDK1/cyclin B and DYRK1A.[Pubmed:23467012]
Molecules. 2013 Mar 6;18(3):3018-27.
In an effort to find potent inhibitors of the protein kinases DYRK1A and CDK1/Cyclin B, a systematic in vitro evaluation of 2,500 plant extracts from New Caledonia and French Guyana was performed. Some extracts were found to strongly inhibit the activity of these kinases. Four aristolactams and one lignan were purified from the ethyl acetate extracts of Oxandra asbeckii and Goniothalamus dumontetii, and eleven aporphine alkaloids were isolated from the alkaloid extracts of Siparuna pachyantha, S. decipiens, S. guianensis and S. poeppigii. Among these compounds, Velutinam, aristolactam AIIIA and medioresinol showed submicromolar IC50 values on DYRK1A.
New constituents from stems of Goniothalamus amuyon.[Pubmed:16819228]
Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1040-3.
Two new compounds, goniothalesacetate (1) and goniothalesdiol A (2) together with goniodiol-7-monoacetate, goniodiol-8-monoacetate, leiocarpin C, liriodenine, griffithazanone A, 4-methyl-2,9,10-(2H)-1-azaanthracencetrione, Velutinam and aristolactam BII were isolated and characterized from the stems of Goniothalamus amuyon. Structures of new compounds were determined by spectral analysis.
Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii.[Pubmed:10978218]
J Nat Prod. 2000 Aug;63(8):1160-3.
Investigation of extracts of Fissistigma balansae and Fissistigma oldhamii resulted in the isolation of 11 aristolactams-stigmalactam (1), piperolactam A (2), piperolactam C (3), aristolactam AII (4), aristolactam AIIIa (5), aristolactam BII (6), aristolactam BIII (7), aristolactam FII (8), goniothalactam (9), enterocarpam I (10), and Velutinam (11)-as well as two dioxoaporphines, noraristolodione (12) and norcepharadione B (13). The new compound 1 was identified by spectral data interpretation. Compounds 1-13 were subjected to antiplatelet aggregation testing.
Alkaloids from the roots of goniothalamus griffithii[Pubmed:10425141]
J Nat Prod. 1999 Jul;62(7):1050-2.
Three new alkaloids-griffithazanone A (1), griffithdione (2), and griffithinam (3)-were isolated from the roots of Goniothalamus griffithii, along with six known compounds, 4-methyl-2,9, 10-(2H)-1-azaanthracenetrione (4), Velutinam, aristololactam BI, aristololactam BII, aristololactam AII, and norcepharanone B. Their structures were elucidated on the basis of spectral and chemical methods. The absolute configuration of griffithazanone A (1) was determined by the preparation of Mosher's esters.
