Yunaconitine

CAS# 70578-24-4

Yunaconitine

Catalog No. BCN6261----Order now to get a substantial discount!

Product Name & Size Price Stock
Yunaconitine: 5mg $81 In Stock
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Quality Control of Yunaconitine

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Chemical structure

Yunaconitine

3D structure

Chemical Properties of Yunaconitine

Cas No. 70578-24-4 SDF Download SDF
PubChem ID 155569 Appearance White powder
Formula C35H49NO11 M.Wt 659.77
Type of Compound Alkaloids Storage Desiccate at -20°C
Synonyms Guayewuanine B
Solubility DMSO : ≥ 250 mg/mL (378.93 mM)
*"≥" means soluble, but saturation unknown.
SMILES CCN1CC2(C(CC(C34C2C(C(C31)C5(CC(C6(CC4C5C6OC(=O)C7=CC=C(C=C7)OC)O)OC)OC(=O)C)OC)OC)O)COC
Standard InChIKey LLEMSCWAKNQHHA-UHFFFAOYSA-N
Standard InChI InChI=1S/C35H49NO11/c1-8-36-16-32(17-41-3)22(38)13-23(43-5)35-21-14-33(40)24(44-6)15-34(47-18(2)37,26(29(35)36)27(45-7)28(32)35)25(21)30(33)46-31(39)19-9-11-20(42-4)12-10-19/h9-12,21-30,38,40H,8,13-17H2,1-7H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Yunaconitine

The root of Aconitum carmichaeli Debx.

Biological Activity of Yunaconitine

Description1. Yunaconitine,extracted from several plants of Aconitum, has anti-inflammatory and analgesic actions. 2. Yunaconitine can increase serum total complement as well as the phag-ocytic activity of reticuloendothelial system in mice, these effects are considered to be beneficial in the clearance of pathogenic antigens, and may be the immunopharmacological basis of antiinflammatory actions of yunaconitine.
TargetsImmunology & Inflammation related

Yunaconitine Dilution Calculator

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Yunaconitine Molarity Calculator

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Preparing Stock Solutions of Yunaconitine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5157 mL 7.5784 mL 15.1568 mL 30.3136 mL 37.892 mL
5 mM 0.3031 mL 1.5157 mL 3.0314 mL 6.0627 mL 7.5784 mL
10 mM 0.1516 mL 0.7578 mL 1.5157 mL 3.0314 mL 3.7892 mL
50 mM 0.0303 mL 0.1516 mL 0.3031 mL 0.6063 mL 0.7578 mL
100 mM 0.0152 mL 0.0758 mL 0.1516 mL 0.3031 mL 0.3789 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Yunaconitine

Yunaconitine(Guayewuanine B) is a highly toxic aconitum alkaloid.

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References on Yunaconitine

Hidden aconite poisoning: identification of yunaconitine and related aconitum alkaloids in urine by liquid chromatography-tandem mass spectrometry.[Pubmed:16959134]

J Anal Toxicol. 2006 Sep;30(7):426-33.

Poisoning from aconite occurs worldwide as a result of misuse of the potent plant. Laboratory investigation into suspected intoxication cases is challenging because the content of toxic aconitum alkaloids varies depending on the plant source, market processing, dosing protocol, hydrolytic degradation, and metabolic transformation. Using a triple-quadrupole tandem mass spectrometer, a group screening method was developed based on the mass-fragmentographic scheme of common aconitum alkaloids. The precursor-ion scans of m/z 105 and 135 permitted selective profiling of 14-O-benzoyl-norditerpenoids and the 14-O-anisoyl-norditerpenoids, respectively. Gradient reversed-phase liquid chromatography minimized coelution of isobaric compounds. The screening protocol was applied to a clinical investigation of suspected herbal poisoning. In total, 15 urine samples were thus screened positive for aconitum alkaloid over 5 years. The diagnoses of aconite poisoning in 11 patients were firmly established based on the known prescription history and the positive urine finding. In four patients, without aconitum herbs being listed in the herbal prescriptions, contamination of the herbal remedies by aconite was suspected to be the hidden cause of their acute poisoning. Yunaconitne, a highly toxic aconitum alkaloid, was thus identified in human urine for the first time. The group screening method of aconitum alkaloids in urine is an important diagnostic aid for acute poisoning by aconites of an unclear origin.

Accelerated solvent extraction and pH-zone-refining counter-current chromatographic purification of yunaconitine and 8-deacetylyunaconitine from Aconitum vilmorinianum Kom.[Pubmed:23784883]

J Sep Sci. 2013 Aug;36(16):2680-5.

This study aimed to seek an efficient method to extract and purify Yunaconitine and 8-deacetylYunaconitine from Aconitum vilmorinianum Kom. by accelerated solvent extraction combined with pH-zone-refining counter-current chromatography. The major extraction parameters for accelerated solvent extraction were optimized by an orthogonal test design L9 (3)(4). Then a separation and purification method was established using pH-zone-refining counter-current chromatography with a two-phase solvent system composed of petroleum ether/ethyl acetate/methanol/water (5:5:2:8, v/v) with 10 mM triethylamine in the upper phase and 10 mM HCl in the lower phase. From 2 g crude extract, 224 mg of 8-deacetylYunaconitine (I) and 841 mg of Yunaconitine (II) were obtained with a purity of over 98.0%. The chemical structures were identified by ESI-MS and (1)H and (13)C NMR spectroscopy.

Description

Yunaconitine(Guayewuanine B) is a highly toxic aconitum alkaloid.

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