VEGFR
Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and vasculogenesis. VEGF binds to and activates a receptor tyrosine kinase, VEGFR, through transphosphorylation. Three VEGFR isoforms have been identified in humans.
Products for VEGFR
- Cat.No. Product Name Information/Activity
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BCC2520
AEE788 (NVP-AEE788)
AEE788 is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, respectively.
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BCC4514
Tyrphostin AG 879
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity.
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BCC2522
Ponatinib (AP24534)
Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
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BCC3729
Axitinib (AG 013736)
Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.
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BCC6196
DMH4
515880-75-8
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BCC6078
(E)-FeCP-oxindole
884338-18-5
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BCC6079
(Z)-FeCP-oxindole
1137967-28-2
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BCC1116
Ki8751
Ki8751 is a potent VEGFR2 inhibitor with an IC50 of 0.9 nM.
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BCC7073
SU 4312
5812-07-7
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BCC1970
SU 5402
SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, respectively.
